Publications by authors named "Mei-chun Gao"
Background And Objectives: Cerebrospinal fluid (CSF) and interstitial fluid exchange along a brain-wide network of perivascular spaces (PVS) termed the 'glymphatic system'. The aquaporin-4 (AQP4) water channels abundantly expressed on astrocytic endfeet play a key role in the CSF circulation in the glymphatic system. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating autoimmune disease of the central nervous system (CNS) featured with a specific autoantibody directed against AQP4 in most of patients.
View Article and Find Full Text PDFArticle Synopsis
- Neuromyelitis Optica spectrum disorder (NMOSD) is a serious autoimmune disease affecting the central nervous system, and the best initial treatment options are still uncertain.
- Researchers will conduct a clinical trial involving 430 NMOSD patients to assess the safety and efficacy of human umbilical cord mesenchymal stem cells (hUC-MSCs), looking for the optimal dosage.
- This trial is significant as it aims to provide the first systematic evaluation of hUC-MSCs' clinical safety and effectiveness for NMOSD, potentially identifying the best treatment dose for patients.
Serum albumin level is associated with the severity of neurological dysfunction of NMOSD patients.
Mult Scler Relat Disord
August 2020
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system. Serum albumin (SA) has antioxidant, immunomodulatory and anti-inflammatory effects. However, the roles of SA in NMOSD have not been studied.
View Article and Find Full Text PDFTh2 axis-related cytokines in patients with neuromyelitis optica spectrum disorders.
CNS Neurosci Ther
January 2018
Aims: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system. Increasing evidence indicates that NMOSD is a Th2- and Th17-dominant disease. IL-25, IL-31, and IL-33 are three newly found Th2-related cytokines, and their roles in the pathogenesis of NMOSD have not been studied.
View Article and Find Full Text PDFBackground: It was still rare for the quantitative magnetic resonance imaging (MRI) research of regional changes in hippocampus sclerosis (HS) in Chinese patients with epilepsy. This study aimed to study the hippocampal volumes (HVs) with quantitative MRI measurement in Chinese patients with epilepsy.
Methods: Forty-six Chinese patients with epilepsy (intractable epilepsy (IE), n = 21; non-intractable epilepsy (NIE), n = 25) and 25 normal controls were collected between July 2007 and March 2008.