Publications by authors named "Mei-Yu Dong"
Article Synopsis
- Researchers developed and tested new antifungal agents based on a unique molecular structure that targets succinate dehydrogenase (SDH), resulting in the creation of 24 '-phenyl-1-pyrazole-4-sulfonohydrazide derivatives.
- The synthesized compounds were found to be effective against various plant pathogenic fungi, with one compound demonstrating potent inhibitory effects similar to a known antifungal, thifluzamide.
- Analyses indicated that the most effective compound damaged fungal mycelium, increased cell membrane permeability, and inhibited SDH enzyme activity, suggesting potential for use as alternatives to existing antifungals.
Aim: To examine the role of nucleostemin in the growth regulation of gastric cancer, liver cancer and other cancers.
Methods: RT-PCR was used to clone the fragment of nucleostemin cDNA from HEK 293 cells. Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization.