Publications by authors named "Mei-You Liu"
Article Synopsis
- The study focuses on Paris polyphylla var. yunnanensis, a plant used in traditional Chinese medicine, aiming to isolate and identify its bioactive saponins.
- Researchers identified fourteen saponins, including seven new compounds, with Paris saponins VII (PSVII) exhibiting strong cytotoxicity against a specific pancreatic cancer cell line (BxPC-3) at low concentrations.
- Further analysis indicated that PSVII could inhibit cell growth and promote cell death through mechanisms involving apoptosis and pyroptosis by activating specific caspases.
SHR0302, as a novel Janus kinase (JAK) inhibitor 1, is used for treatment of rheumatoid arthritis (RA) in humans. A novel and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has been developed and validated for determining the concentration of SHR0302 in human plasma. A precipitation deproteinization method was used for plasma pretreatment with methanol.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) cells rapidly switch their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate. However, the molecular mechanisms responsible for this switch remain unclear. In this study, we found that miR-592 was frequently downregulated in human HCC tissues and cell lines, and its downregulation was closely correlated with aggressive clinicopathological features and poor prognosis of HCC patients.
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