MiR-101-3p inhibits EMT to attenuate proliferation and metastasis in glioblastoma by targeting TRIM44.

Background: Glioblastoma (GBM) is the most common malignant tumor originating in the brain parenchyma. The invasive and infiltrative properties of glioblastoma result in poor clinical prognosis to conventional therapies. Emerging reports on microRNAs as important regulators during the process of EMT provide new insights into treating glioblastoma through new targets.

Effects of combined exogenous dextranase and sodium fluoride on Streptococcus mutans 25175 monospecies biofilms.

Purpose: To investigate the effects of exogenous dextranase and sodium fluoride on a S. mutans monospecies biofilm.

Methods: S.

The effects of light on bleaching and tooth sensitivity during in-office vital bleaching: a systematic review and meta-analysis.

Objective: To evaluate the influence of light on bleaching efficacy and tooth sensitivity during in-office vital bleaching.

Data Sources: We performed a literature search using Medline, EMBASE and Cochrane Central up to September 2011.

Study Selection: All randomised controlled trials (RCTs) or quasi-RCTs comparing the light-activated bleaching system with non-activation bleaching system were included.

The presence of open dentinal tubules affects the biological properties of dental pulp cells ex vivo.

To investigate the effects of open dentinal tubules on the morphological and functional characteristics of dental pulp cells. Morphological changes in human dental pulp cells that were seeded onto dentin discs with open dentinal tubules were investigated on days 1, 2, 4, and 10 of culture using scanning electron microscopy and fluorescence microscopy. Samples collected on days 1, 3, 6, 8, and 10 of culture were evaluated for cell proliferation rate and alkaline phosphatase activity.

β-Catenin and Rho GTPases as downstream targets of TGF-β1 during pulp repair.

TGF-β1 (transforming growth factor-β1) plays a central role in regulating proliferation, migration and differentiation of dental pulp cells during the repair process after tooth injury. Our previous study showed that p38 mitogen-activated protein kinase may act downstream of TGF-β1 signalling to effect the differentiation of dental pulp cells. However, the molecular mechanisms that trigger and regulate the process remain to be elucidated.

Roles of lysophosphatidic acid and the Rho-associated kinase pathway in the migration of dental pulp cells.

During the dental pulp repair process, dental pulp cells (DPCs) migrate to the site of injury and differentiate into odontoblasts or odontoblast-like cells. Although migration of DPCs is an important reparative process, the underlying mechanism remains unknown. The objective of this study was to determine the roles of lysophosphatidic acid (LPA) and the Rho-associated kinase (ROCK) pathway in the migration and morphology of dental pulp cells and alpha smooth muscle actin expression in vitro.

Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis.

Objective: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted.

Material And Methods: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles.

Dental erosion and severe tooth decay related to soft drinks: a case report and literature review.

Soft drinks have many potential health problems. The inherent acids and sugars have both acidogenic and cariogenic potential, resulting in dental caries and potential enamel erosion. In this report we present a 25-year-old man complaining with the severe worn-out of the front teeth during the past 3 years.