Pharmacokinetics of intracameral voriconazole injection.

Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-microg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis.

Clearance of intravitreal voriconazole.

Unlabelled: Purpose To investigate the elimination rate of voriconazole after intravitreal injection in rabbits.

Methods: Intravitreal injections of 35 microg/0.1 mL voriconazole were administered to rabbits.