Publications by authors named "Mei-Yee Meng"
A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian descent compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and it is associated with an increased risk for breast cancer in Asian women. Here, we explored the relationship between the A3B deletion polymorphism with tumour characteristics in Asian women.
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- Molecular profiling of breast cancer has led to better prognostic tools and treatment options, but non-Caucasian populations, particularly Malaysian women, are often neglected in research.
- In a study of 560 Malaysian breast tumors, researchers found more HER2-enriched subtypes and TP53 mutations in Asian women compared to Caucasian women, indicating distinct molecular characteristics.
- The findings suggest that certain tumor characteristics in Asian breast cancer may lead to improved survival and responses to treatments, highlighting the need for personalized medicine approaches that consider these population differences.