Neogrisphenol A, a Potential Ovarian Cancer Inhibitor from a New Record Fungus .

From the rice fermentation product of a new record fungus, , two new polyketides, neogrisphenol A () and neogrisphenol B (), one new isochroman-1-one, ()-6-hydroxy-7-methoxy-3,5-dimethylisochroman-1-one (), and four known compounds (-) were isolated. Their structures were determined using 1D- and 2D-NMR, mass spectrometry, and chemical calculations. The C-3~C-2' polymerization mode between the two -naphthalenone derivative moieties is uncommon in compounds and .

[Establishment and application of median serum markers for second trimester screening in Qingdao region].

Objective: To establish the median of serum markers for second trimester screening in Qingdao region and to assess the influence of median correction on the performance of screening.

Methods: Maternal serum alpha-fetoproteins (AFP), human chorionic gonadotrophin, free beta subunit (β -HCG) and unconjugated oestriol (uE3) were assayed for prenatal screening of 18 188 singleton pregnancies at 15-20(+ 6) weeks gestation from January 2009 to July 2010. The median of serum markers was calculated based on above results and applied for risk estimation in screening for fetal aneuploidy from August 2010 to March 2011.

[Evaluation of Down's syndrome screening methods using maternal serum biochemistry in the second trimester pregnancy].

Objective: To provide basis for selecting the suitable method of Down's syndrome biochemical screening in the second trimester pregnancy.

Methods: A total of 30 547 singleton pregnancies between 14 and 20(+ 6) weeks of pregnancy were collected and analyzed for maternal serum alpha-fetoproteins (AFP) and human chorionic gonadotrophin, free beta subunit (beta-HCG) with or without unconjugated estriol (uE3). The screening risks were calculated using the software Lifecycle.