Publications by authors named "Mei-Xin Fang"
Article Synopsis
- * A study of 142 pediatric AML patients found nine with NUP98-r mutations, which were associated with distinct genomic features and a higher frequency of FLT3-ITD mutations compared to patients without these rearrangements.
- * Results showed that NUP98-r mutations led to worse relapse-free and overall survival rates, highlighting the need for targeted risk assessment and treatment strategies in pediatric AML cases with these mutations.
[Study on Down-regulation of Interleukin-1β Secretion by Inhibiting ABCC1/MRP1 Transporter].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2024
Article Synopsis
- - The study aimed to identify membrane transporters related to the secretion of interleukin (IL)-1β from macrophages using experiments with human cell lines and knockout mice models.
- - Human macrophages were created from the THP-1 cell line and primary blood cells, and various transporter inhibitors were tested for their impact on IL-1β secretion after being stimulated.
- - Results showed that inhibiting the ABCC1/MRP1 transporter significantly reduced IL-1β secretion, suggesting it as a potential target for treating issues such as cytokine release syndrome.
An improved, sensitive, specific, and rapid one-step reverse transcription loop-mediated isothermal amplification (LAMP) assay targeting the 5' untranslated region (UTR) was developed to detect hepatitis C virus (HCV) infection. Based on an accelerating primer (AP), the present assay, named AP-LAMP, has the advantages of rapidity and sensitivity over the routine LAMP method. The possible AP-based amplification pathway during the reaction was revealed by restriction enzyme digestion and eletrophoresis.
View Article and Find Full Text PDFObjective: To study the expression of CD38 and HLA-DR on CD8(+) T cells in pediatric AIDS patients receiving highly active antiretroviral therapy (HAART) and the relationship of immune activation and disease progression.
Methods: A cross-section study of 194 pediatric AIDS patients receiving HAART was carried out and 52 age-matched healthy children were recruited as control. The percentage of CD4(+), CD8(+), CD8(+)/CD38(+) and CD8(+)/HLA-DR(+) T cells was tested using flow cytometry, and HIV-RNA in plasma was detected by quantitative RT-PCR.