Publications by authors named "Mei-Wen Huang"

This study aimed to explore the intervention effect of Chuanxiong-Chishao herb pair(CX-CS) on a myocardial infarction-atherosclerosis(MI-AS) mouse model and investigate its effect on the expression profile of circular RNAs(circRNAs)/long non-coding RNAs(lncRNAs) in ischemic myocardium and aorta. Sixty male ApoE~(-/-) mice were randomly assigned to a model group, high-, medium-, and low-dose CX-CS groups(7.8, 3.

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In this study, the compound search was completed through SciFinder and CNKI databases, and the drug-like properties were screened in FAFdrugs4 and SEA Search Server databases. In addition, based on the target sets related to acute myocardial ischemia(AMI) searched in disease target databases such as OMIM database, GeneCards database and DrugBank, a network diagram of chemical component-target-pathway-disease was established via Cytoscape to predict the potential active components of Corydalis Herba, a traditional Tibetan herbal medicine which derived from the aerial parts of Corydalis hendersonii and C. mucronifera against AMI.

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Rhus chinensis is an important resource plant. The aqueous extract of R. chinensis roots or stems was to produce Shuguantong Syrup, which is mainly used for the treatment of coronary heart disease and angina pectoris with definite curative effect.

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Article Synopsis
  • - The genus Syringa, part of the Oleaceae family, includes over 20 species, with about 16 species, including 10 endemic ones, found in China.
  • - Syringa species are commonly used for herbal medicine and ornamental purposes, particularly S. pinnatifolia, which is used in traditional Mongolian medicine for cardiovascular and pulmonary issues.
  • - This review updates research from 2015 on the phytochemical and pharmacological properties of Syringa, aiming to enhance understanding and applications in medicine.
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Article Synopsis
  • * The paper explores how integrating ethnomedicine with network pharmacology can offer insights into the holistic prevention and treatment strategies of ethnic medicinal practices.
  • * It also discusses the current challenges in this field, including issues like inaccurate data, the need for better network analysis platforms, and underdeveloped basic research in ethnomedicine, while suggesting future directions to overcome these obstacles.
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Emx2 deletion impairs the growth and maintenance of the genital ridge. However, its role in subsequent germ cell differentiation during embryonic stages is unknown. Using a tamoxifen-inducible Cre-loxP mouse model (Emx2(flox/flox), Cre-ER(TM), hereafter called as Emx2 knockdown), we showed that germ cell differentiation was impaired in Emx2-knockdown testes.

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Diallyl sulfide (DAS), one of the major organosulfur compounds (OSCs) of garlic, is recognized as a group of potential chemoproventive compounds. In this study, we examines the early signaling effects of DAS on renal cells loaded with Ca(2+)-sensitive dye fura-2. It was found that DAS caused an immediate and sustained rise of [Ca(2+)](i) in a concentration-dependent manner (EC(50)=2.

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