An injectable sodium-mangiferin homopolymeric hydrogel accelerated skin full-thickness wound healing in guinea pig model.

In the treatment of joints, mucosa, and full-thickness wounds, traditional implant surgery presents not only inconvenience but also a significant risk of wound infection. Additionally, the pharmaceutical application of mangiferin(MGF) has been severely restricted due to its poor water solubility. In this study, we reported the synthesis and characterization of sodium-mangiferin (MGF-Na(S)) using the salt formation method.

Characteristics and trends in diagnosis of Kawasaki disease outside the usual age range.

Objective: To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years.

Method: A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed.

Results: A total of 8416 patients were included.

Epidemiologic Features of Kawasaki Disease in Shanghai From 2013 Through 2017.

Background: We sought to investigate epidemiologic features of Kawasaki disease (KD) in Shanghai from 2013 through 2017 and identify risk factors for coronary artery lesions (CAL).

Methods: As in our previous three surveys, a set of questionnaires and diagnostic guidelines for KD were sent to 50 hospitals providing pediatric medical care in Shanghai. Medical records of KD patients diagnosed from January 2013 through December 2017 were retrospectively analyzed.

Synthesis of poly(1,5-diaminonaphthalene) microparticles with abundant amino and imino groups as strong adsorbers for heavy metal ions.

Poly(1,5-diaminonaphthalene) microparticles with abundant reactive amino and imino groups on their surface were synthesized by one-step oxidative polymerization of 1,5-diaminonaphthalene using ammonium persulfate as the oxidant. The molecular, supramolecular, and morphological structures of the microparticles were systematically characterized by IR and UV-vis spectroscopies, elementary analysis, wide-angle X-ray diffractometry, and transmission electron microscopy. The microparticles demonstrate electrical semiconductivity and high resistance to strong acid and alkali, and strong adsorption capability for lead(II), mercury(II), and silver(I) ions.

Efficient synthesis of oligofluoranthene nanorods with tunable functionalities.

Strongly fluorescence-emitting oligofluoranthene (OFA) nanorods are readily synthesized by a direct template-free chemical oxidative oligomerization of fluoranthene in nitromethane containing ferric chloride as an oxidant. The OFAs likely consist of five fluoranthene units containing cyclic pentamers with crystalline order and tunable electrical conductivity across 12 orders of magnitude. The OFA nanorods are heat-resistant materials and efficient precursors for macroporous carbon materials with high carbon yield in argon at 1100 °C.

Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012.

Background: This study was to investigate the epidemiologic trends of Kawasaki disease (KD) and coronary arterial lesions (CALs) in Shanghai from 2008 through 2012.

Methods: Data were collected by using the network of the KD research group established during the first survey in Shanghai to conduct the third survey, covering the period from 2008 through 2012. Clinical records of 2304 patients with acute KD were retrospectively reviewed.

[Spd1672 gene knockout significantly attenuates the virulence of Streptococcus pneumoniae].

Objective: To investigate the role of spd1672 gene in the infection process of Streptococcus pneumoniae.

Methods: BALB/c mice were intraperitoneally infected by a spd1672 knockout strain and a D39 wild-type strain of S. pneumoniae, and the survival time of mice and blood bacterial counts were recorded.

Interfacial chemical oxidative synthesis of multifunctional polyfluoranthene.

A novel polyfluoranthene (PFA) exhibiting strong visual fluorescence emission, a highly amplified quenching effect, and widely controllable electrical conductivity is synthesized by the direct cationic oxidative polymerization of fluoranthene in a dynamic interface between -hexane and nitromethane containing fluoranthene and FeCl, respectively. A full characterization of the molecular structure signifies that the PFAs have a degree of polymerization from 22-50 depending on the polymerization conditions. A polymerization mechanism at the interface of the hexane/nitromethane biphasic system is proposed.

Synthesis of semiconducting polymer microparticles as solid ionophore with abundant complexing sites for long-life Pb(II) sensors.

Intrinsically electrically semiconducting microparticles of semiladder poly(m-phenylenediamine-co-2-hydroxy-5-sulfonic aniline) structures containing abundant functional groups, like -NH-, -N=, -NH2, -OH, -SO3H as complexation sites, were efficiently synthesized by chemical oxidative copolymerization of m-phenylenediamine and 2-hydroxy-5-sulfonic aniline. The obtained copolymers were found to be nonporous spherical microparticles that were able to achieve greater π-conjugated structure, smaller particle aggregate size, and stronger interaction with Pb(II) ions than poly(m-phenylenediamine) containing only -NH-, -N=, and -NH2. A potentiometric Pb(II) sensor was fabricated on the basis of the copolymer microparticles as a crucial solid ionophore component within plasticized PVC.

Coronary artery indexed diameter and z score regression equations in healthy Chinese Han children.

Objective: In children with coronary disease, clinical decision should be based on detailed measurements of the coronary arteries by two-dimensional echocardiography. We aimed to establish coronary artery reference indexed diameter and z scores regression equations in a large cohort of Chinese Han children.

Methods: We measured the diameter of the proximal right (RCA), left main (LMCA), left anterior descending, and left circumflex coronary artery, and of the aortic annulus, and calculated the coronary-aorta index (coronary artery-to-aortic annulus ratio) in 506 Chinese Han children with normal hearts whose ages ranged from 1 day to 18 years.

Combinatorial screening of potentiometric Pb(II) sensors from polysulfoaminoanthraquinone solid ionophore.

A potentiometric Pb(II)-selective sensor was fabricated by a combinatorial screening of electrically conducting polysulfoaminoanthraquinone (PSA) nanoparticles as a solid ionophore, ion exchangers (oleic acid (OA) and NaTPB), plasticizers in a polyvinyl chloride (PVC) matrix, membrane thickness, inner filling ion species, and concentration. The membrane sensor with the composition of PSA/PVC/DOP (dioctyl phthalate)/OA (1.0:33:61:5.

[Clinical characteristics and prognosis of infantile-onset glycogen storage disease type II in 16 Chinese patients].

Objective: To explore the clinical characteristics and prognosis of infantile-onset glycogen storage disease type II (GSDII) in Chinese patients.

Methods: Sixteen children diagnosed as infantile-onset GSDII in Shanghai Children's Medical Center during Jan 2005 to Dec 2012 were recruited. Their disease history, presenting symptom, physical signs, biochemical tests and examinations of electrocardiogram and echocardiography were analyzed retrospectively.

Lead-ion potentiometric sensor based on electrically conducting microparticles of sulfonic phenylenediamine copolymer.

A potentiometric sensor to detect lead ions using newly synthesized conducting copolymer microparticles as an ionophore in self-supporting poly(vinyl chloride) membrane matrix plasticized with dioctyl phthalate was developed. The copolymer microparticles containing many ligating functional groups including amino, imino and sulfonic groups were synthesized by a chemical oxidative copolymerization of m-phenylenediamine (mPD) and p-sulfonic-m-phenylenediamine (SPD) in pure water. Due to the presence of -NH-, -N=, -NH2, and -SO3H ligating groups on the microparticles, a linear Nernstian response is obtained within a Pb(II) activity range from 1.

[Transcatheter closure of patent ductus arteriosus with the new Amplatzer Duct OccluderII].

Objective: To evaluate the indications, methodology and results of the transcatheter closure of patent ductus arteriosus (PDA) with the new Amplatzer Duct Occluder II (ADO-II).

Method: Totally 51 patients underwent transcatheter closure of PDA with the new ADO-II. The devices were delivered by 4F or 5F sheath through arterial or venous side respectively.

[Clinical presentation and therapeutic outcomes of carnitine deficiency-induced cardiomyopathy].

Objective: Carnitine deficiency has been associated with progressive cardiomyopathy due to compromised energy metabolism. The objective of this study was to investigate clinical features of carnitine deficiency-induced cardiomyopathy and the therapeutic efficacy of L-carnitine administration.

Method: Between January 2010 and December 2011, filter-paper blood spots were collected from 75 children with cardiomyopathy.

[Efficacy of the transcatheter closure of perimembranous and muscular ventricular septal defects with the Amplatzer duct occluder II].

Objectives: To evaluate the feasibility and efficacy of transcatheter closure of perimembranous ventricular septal defects (pmVSD) with aneurysmatic formation and muscular ventricular septal defects (mVSD) with Amplatzer duct occluder II.

Methods: This retrospective analysis included 48 cases received transcatheter closure of pmVSD aneurysmatic formation or mVSD from February 2011 to March 2012 in our hospital (42 pmVSD with aneurysmatic formation and 6 mVSD). Median age was 5.

Interfacial synthesis and functionality of self-stabilized polydiaminonaphthalene nanoparticles.

A simple and effective template-free synthesis method for nanosized conducting polymers with self-stability and functionality is a main challenge. Herein, a strategy is reported for the facile synthesis of poly(1,5-diaminonaphthalene) nanospherical particles by an interfacial miniemulsion oxidative polymerization of 1,5-diaminonaphthalene at mobile microinterfaces between a stirred biphase without external emulsifiers. The size of the nanospheres was carefully optimized by controlling the polymerization conditions.

[Adenosine for pulmonary vasodilator testing in children with idiopathic pulmonary arterial hypertension].

Objective: The assessment of pulmonary vascular reactivity plays an important role in the management of idiopathic pulmonary arterial hypertension (IPAH). The aim of this study was to explore the indications and methodology of pulmonary vasodilator testing in children with IPAH.

Methods: From October 2009 to June 2011, a cohort of pediatric patients with IPAH in WHO functional classes II to III were enrolled in the study.

Ultrasensitive Pb(II) potentiometric sensor based on copolyaniline nanoparticles in a plasticizer-free membrane with a long lifetime.

A newly designed Pb(II) potentiometric sensor based on intrinsically conducting nanoparticles of solid poly(aniline-co-2-hydroxy-5-sulfonic aniline) possessing many ligating functional groups like -NH-, -N=, -OH, -SO(3)H, -NH(2) as ionophores in plasticizer-free vinyl resin solid membranes has been fabricated. A linear Nernstian response is obtained within a wide Pb(II) activity range from 1.0 × 10(-3) to 1.

Lead ion-selective electrodes based on polyphenylenediamine as unique solid ionophores.

A novel membrane electrode for Pb(II) ion detection based on semi-conducting poly(m-phenylenediamine) microparticles as a unique solid ionophore was fabricated. The electrode exhibited significantly enhanced response towards Pb(II) over the concentration range from 3.16×10(-6) to 0.

[Evaluation of early monitoring of cardiotoxicity induced by anthracyclines].

Objective: Anthracyclines (ANT) are effective for leukemia and solid tumors. However the long-term life quality of patients is seriously affected by ANT-related cardiotoxicity. The aim of this study was to evaluate the value of two dimension echocardiography (2DE) and serum biochemical indicators in monitoring ANT-related cardiotoxicity.

Cheatham-Platinum stent implantation for pulmonary artery stenosis in children and adolescents: immediate and mid-term outcome.

Background: NuMED Cheatham-Platinum (CP) stent implantation for pulmonary artery stenosis in children and adolescents has been rarely reported. This study aimed to evaluate the immediate and mid-term results of CP stent implantation for the treatment of pulmonary artery stenosis associated with congenital heart disease (CHD) in children and adolescents.

Methods: From August 2005 to May 2007, four consecutive pediatric patients with pulmonary artery stenosis associated with CHD underwent CP stent implantation.