Publications by authors named "Mei-Qi Wan"
Article Synopsis
- * A study evaluated 35 SPC constituents using a specific analytical method (UFLC-MS/MS) to assess their absorption and transport properties in a human intestinal model (Caco-2 cells), leading to the classification of their permeability.
- * The research identified that seven well-absorbed SPC compounds primarily use passive diffusion for absorption, while their chemical structures influence their permeability rates across the cell monolayer.
Article Synopsis
- * The study utilized a UPLC-Q-TOF-MS method combined with metabonomics to analyze APR metabolites in rats, investigating plasma, urine, and feces samples.
- * A total of 213 compounds were identified, including 41 original ingredients and 134 potential new metabolites, providing valuable insights for future clinical applications.
Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine (TCM), is mainly used to treat rheumatism and headache diseases. Angelol B is one of the bioactive constituents of APR with significant anti-inflammatory activity. This paper is aimed to illustrate the metabolites of angelol B in vivo.
View Article and Find Full Text PDFObjectives: The primary objective of the study was to assess the rationale of fentanyl patch initiation and continuation for pain. The secondary objectives were to analyse prescribing pattern between disciplines, monitoring criteria and adverse events profile of fentanyl patch in the inpatient wards for a tertiary hospital.
Methods: A retrospective case series review was undertaken of patients who received transdermal fentanyl for pain from April to June 2013 at the National University Hospital, Singapore.
Aminoglycoside-associated acute kidney injury in elderly patients with and without shock.
J Antimicrob Chemother
November 2016
Objectives: Multiresistant Gram-negative pathogens pose major healthcare concerns with a limited therapeutic armamentarium. Aminoglycosides (AG) are under-utilized due to nephrotoxicity. We aimed to evaluate AG-associated acute kidney injury (AG-AKI) in elderly inpatients, with and without shock.
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