Publications by authors named "Mei-Nan Yao"
Article Synopsis
- Reproductive capacity in both animals and women decreases with age, with ovarian aging being a key factor, but the effects of uterine aging are still not fully understood.
- A study comparing pregnancy rates and uterine hormone responsiveness in ovariectomized mice revealed a notable decline in implantation and pregnancy rates as the mice aged from 2 months to 12 months.
- The research found significant hormonal changes in the older mice, indicating that altered steroid hormone responsiveness might play a role in reduced pregnancy success in aged subjects.
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The expression of Lcn2 in stromal cells is under the control of progesterone through Akt-c-Myc signaling pathway.
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