Publications by authors named "Mei-Na Liao"
The wastewater treatment processes (WTP) on pig farms are heavily contaminated by antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) play an important role in shaping ARG profiles. Here we first employed metagenomic sequencing to follow the diversities and shifts of ARG associated mobile genetic elements (AAMGEs) including insertion sequences (ISs) and plasmids along the WTP for three pig farms in southeast China. The IS average relative abundance rose from the initial pig feces source to the wastewater storage lagoon (WSL) but decreased in the influent and rose in the effluent of the anaerobic digestor (AD).
View Article and Find Full Text PDFThe emergence of (X) genes has compromised the clinical use of the last-line antibiotic tigecycline. We identified 322 (1.21%) (X) positive samples from 12,829 human microbiome samples distributed in four continents (Asia, Europe, North America, and South America) using retrospective data from worldwide.
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- * Out of these, 49 isolates were found to have high-level resistance and carried resistance genes on plasmids, with one prevalent sequence type (ST6856) being identified in 24.5% of resistant isolates.
- * Our findings suggest that the pigeon farm may be a significant reservoir for these resistant bacteria, posing a potential risk for human infections, and highlight the need for ongoing monitoring.