Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1.

Aims: To screen coral-derived compounds with neuroprotective activity and clarify the potential mechanism of lead compounds.

Methods: The lead compounds with neuroprotective effects were screened by H O and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP )-induced cell damage models in SH-SY5Y cells. CCK8 and LDH assays were used to detect cell viability.