[Effect of oral administration of icariin on periodontitis associated alveolar bone resorption in an osteoporosis mouse model].

Purpose: To study the effect of oral administration of icariin (ICA) on periodontitis associated alveolar bone resorption in an osteoporosis mouse model.

Methods: Three-month old, female C57BL/6J mice were randomly divided into 3 groups: normal group (SHAM), ovariectomy + oral smearing of Porphyromonas gingivalis (Pg) + icariin group (OVX+Pg+ICA), ovariectomy+ Pg group (OVX+Pg). On the second week, the mice underwent ovariectomy to induce osteoporosis.

Drug screening study using glioma stem-like cells.

Glioma is one of the most common malignant tumors affecting the central nervous system. We screened active drugs from 12 classes to provide experimental data for the study of human glioma. Serum-free suspension clone formation was used to induce the formation of glioma stem‑like cells (GSLCs) from U251 cells.

Protective effect of 7-difluoromethoxy-5,4'-Di-hydroxyl isoflavone against the damage induced by glutamate in PC12 cells.

7-difluoromethoxy-5,4'-Di-hydroxyl isoflavone (dFGEN), prepared by the difluoromethylation of genistein, is an active chemical entity. In this study, our main purpose was to investigate whether dFGEN had an effect on glutamate-induced apoptosis in cultured PC12 cells. The PC12 cells were treated with different glutamate concentrations for 24 h in vitro.