A fluorescent probe derived from Berberrubine for detecting hydrogen polysulfide in food samples.

In this work, we chose the fluorophore Berberrubine to develop a selective probe for hydrogen polysulfide (HS), and applied it into the detection in both food samples and living cells. The developed probe, HER9SS, suggested practical steadiness and serviceability, especially for multi-scene detection. The detecting system was stable in relatively wide pH (7.

A berberrubine-derived fluorescent probe for hydrazine and its practical application in water and food samples.

In this work, we attempted to develop a fluorescent probe for hydrazine in real samples. Accordingly, we designed BER9-HZ to fulfill the set rules as solubility, anti-interference capability and functional compatibility. The selected reporting group BER9 dissolved 100% within 10 min, which indicated much better solubility than Berberine.

Beetleane A and Epicoane A: Two Carbon Skeletons Produced by .

Two novel natural products, beetleane A () and epicoane A (), were obtained from the metabolites of an endophytic . Compound has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.

Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from .

The new polycyclic polyprenylated acylphloroglucinols, hyperforcinols A-J (-), were isolated from the fruits of , together with 30 biogenetic congeners of known structures. The structures of hyperforcinols A-J were determined by HRESIMS and 1D/2D NMR spectroscopic analysis, and their absolute configurations were determined by a combination of the electronic circular dichroism (ECD) exciton chirality method, ECD calculations, and X-ray diffraction analysis. A selection of 25 isolates, possessing seven types of carbon skeletons, were assessed for their in vitro effects against nonalcoholic steatohepatitis (NASH) using a free fatty acid-induced L02 cell model.

Pathogenesis of NASH and Promising Natural Products.

Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. The mechanism of the diaease progression, which is lacking effective therapy, remains obsure. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies.

Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.

Non-alcoholic steatohepatitis (NASH) is the progressive stage of non-alcoholic fatty liver disease that may ultimately lead to cirrhosis and liver cancer, and there are few therapeutic options for its treatment. Physalin B (PB), a withanolide isolated from Physalis species (Solanaceae), exhibits a broad spectrum of biological activities, however, the potential role of PB in NASH has not been evaluated. The present study investigated the protective effects of PB against NASH and further elucidated the mechanisms of PB in hepatic autophagy and oxidative stress in vitro and in vivo.

Taxodisones A and B: bioactive C-terpenes with new skeletons from Taxodium distichum and their biosynthetic origin.

Taxodisones A and B, C30-terpenes with an unprecedented tetracyclo[12.4.0.