Publications by authors named "Mei-Hsin Su"

Article Synopsis
  • This study investigated the genetic links between schizophrenia (SCZ) and bipolar disorder (BPD), focusing on how polygenic risks for these disorders relate to education and cognitive aging.
  • Analyzing data from over 106,000 participants, researchers found that certain genetic scores positively correlated with educational achievement, while others had a negative impact.
  • The findings indicate that SCZ and BPD have different genetic influences, affecting educational success and cognitive decline, suggesting that these disorders are not genetically the same.
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The mechanism underlying the co-occurrence of major depressive disorder (MDD) and gynecological diseases remains unclear. This study aimed to investigate the familial co-aggregation and shared genetic loading between MDD and gynecological diseases, namely dysmenorrhea, endometriosis, uterine leiomyomas (UL), and polycystic ovary syndrome (PCOS). Overall, 2,121,632 females born 1970-1999 with parental information were enrolled from the Taiwan National Health Insurance Research Database (NHIRD); 25,142 same-sex twins and 951,779 persons with full-sibling(s) were selected.

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Emerging evidence has shown that assortative mating (AM) is a key factor that shapes the landscape of complex human traits. It can increase the overall prevalence of disorders, influence occurrences of comorbidities, and bias estimation of genetic architectures. However, there is lack of large-scale studies to examine the cultural differences and the generational trends of AM for psychiatric disorders.

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Background: It has been proposed that having a psychiatric disorder could increase the risk of developing a gastrointestinal disorder, and vice versa. The role of familial coaggregation and shared genetic loading between psychiatric and gastrointestinal disorders remains unclear.

Methods: This study used the Taiwan National Health Insurance Research Database; 4,504,612 individuals born 1970-1999 with parental information, 51,664 same-sex twins, and 3,322,959 persons with full-sibling(s) were enrolled.

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To comprehensively investigate the risk factors associated with depression, traditional Chinese medicine constitution (TCMC) has been found to be related to depression. However, the underlying mechanism remains unclear. This study examined the association between the concept of unbalanced TCMCs and major depressive disorder (MDD), investigated the overlapping polygenic risks between unbalanced TCMC and MDD, and performed a mediation test to establish potential pathways.

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Article Synopsis
  • - This study examined the link between mood disorders (like major depressive disorder and bipolar disorder) and substance use (such as tobacco, alcohol, and betel nut), analyzing data from over 132,000 participants in the Taiwan Biobank.
  • - Results showed that major depressive disorder (MDD) was positively associated with patterns of substance use, including alcohol and tobacco, while bipolar disorder (BPD) was connected to earlier onset of smoking, with genetic risk factors (polygenic risk scores) influencing alcohol and tobacco use primarily in females.
  • - Despite the findings, the study's reliance on self-reported data for diagnosing mood disorders and substance use raises questions about accuracy, but the conclusions emphasize the need for targeted prevention and intervention
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Objectives: To assess the causal influence of sleep and circadian traits on coronary artery disease and sudden cardiac arrest with adjustment for obesity through a two-sample Mendelian randomization study.

Methods: We used summary statistics of 5 sleep and circadian traits for genome-wide association studies, including chronotype, sleep duration, long sleep (≥9 h a day), short sleep (<7 h a day), and insomnia (sample size range: 237,622-651,295). Coronary artery disease genome-wide association studies with 60,801 cases and 123,504 controls, sudden cardiac arrest genome-wide association studies with 3939 cases and 25,989 controls, and obesity genome-wide association studies with 806,834 individuals were also used.

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Background: The comorbidity of obesity and major depressive disorder (MDD) may be attributable to a bidirectional relationship and shared genetic influence. We aimed to examine the polygenic associations between obesity and MDD and to characterize their corresponding impacts on the obesity mechanism.

Methods: Genome-wide genotyping was available in 106,604 unrelated individuals from Taiwan Biobank.

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Article Synopsis
  • Cigarette smoking has been linked to schizophrenia risk in observational studies, with causal effects identified in European populations but not in East Asian participants.
  • A study utilizing the Taiwan Biobank (TWBB) and Biobank Japan (BBJ) found genetic loci related to smoking behaviors, contributing to a total analysis of almost 250,000 individuals for smoking initiation and about 46,000 for onset age.
  • The Mendelian randomization approach showed no significant causal relationship between smoking initiation or onset age and schizophrenia in East Asia, although results align with findings from European ancestry samples, suggesting possible genetic influences.
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Background: Obesity has been associated with cognition in observational studies; however, whether its effect is confounding or a reverse causality remains inconclusive. This study aimed to investigate the causal relationships of overall obesity, measured by body mass index (BMI), and abdominal adiposity, measured by waist-hip ratio adjusted for BMI (WHRadjBMI), and cognition across European and Asian populations using Mendelian randomization (MR) analysis.

Methods: We used publicly available genome-wide association study (GWAS) summary data of European ancestry, including BMI (n = 322,154) and WHRadjBMI (n = 210,088) from the GIANT consortium, and cognition performance (n = 257,828) from the UK Biobank and COGENT consortium.

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Aims/hypothesis: Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation of common psychiatric disorders and type 2 diabetes by testing family history association, and investigated the shared genetic loading between them by testing the polygenic risk score (PRS) association.

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Importance: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.

Objective: To investigate the genetics of depression among individuals of East Asian and European descent living in different geographic locations, and with different outcome definitions for depression.

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Schizophrenia and substance involvement frequently co-occur in individuals, and a bidirectional relationship between the two has been proposed; shared underlying genetic factors could be an alternative explanation. This study investigated the genetic overlap between schizophrenia and substance involvement, including tobacco, alcohol and betel nut use. The study subjects were recruited from the Taiwan Biobank, and genome-wide genotyping data was available for 18 327 participants without schizophrenia.

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Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with strong genetic components. Several recent genome-wide association (GWA) studies in Caucasian samples have reported a number of gene regions and loci correlated with the risk of ASD--albeit with very little consensus across studies.

Methods: A two-stage GWA study was employed to identify common genetic variants for ASD in the Taiwanese Han population.

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Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively.

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