Visible-light-driven oxidation of organosilanes by a charge-transfer complex.

Direct oxidation of organosilanes is one of the most straightforward ways to access silanols. Herein, we describe a novel photo-induced strategy for oxidation of organosilanes to access silanols, promoted by a photoactive charge-transfer complex (CTC) between sodium benzenesulfinate and molecular O. A streamlined sequence transformation of organosilanes to silyl ethers was also readily achieved.

Photoredox-catalysed chlorination of quinoxalin-2(1)-ones enabled by using CHCl as a chlorine source.

A photoredox-catalysed chlorination of quinoxalin-2(1)-ones was developed by using CHCl as a chlorine source, thus affording various 3-chloroquinoxalin-2(1)-ones in moderate to high yields. This protocol is characterized by mild reaction conditions, excellent regioselectivity, and readily available chlorination agent. Considering the operational simplicity and low cost of this chlorination approach, this developed method offers an innovative pathway for rapid incorporation of chlorine functionality into heteroarenes, and will inspire broader exploitation of new chlorination strategies.

Photoredox-Catalyzed C-H Trideuteromethylation of Quinoxalin-2(1)-ones with CDCl as the "CD" source.

Herein, readily available and inexpensive CDCl was first identified as a new trideuteromethylation reagent under photoredox-catalyzed conditions. Thus, a facile photocatalytic protocol for the C-H trideuteromethylation of quinoxalin-2(1)-one was achieved. This operationally straightforward transformation displays a broad scope and provides a new route to introduce the trideuteromethyl group (CD) with excellent levels of deuterium content.

Photocatalyzed Defluorinative Dichloromethylation of α-CF Alkenes Using CHCl as the Radical Source.

A visible-light-induced defluorinative dichloromethylation of α-CF alkenes was developed with cheap and readily accessible chloroform simultaneously as a dichloromethylation reagent and reaction medium, leading to the facile preparation of new polyhalogenated scaffolds. Notably, the change from CHCl to CDCl offers a straightforward pathway for accessing the deuterated analogues with excellent degrees of D incorporation. Mechanistic studies suggested the reaction underwent a radical addition of the dichloromethyl radical with alkenes, followed by sequential single-electron transfer and defluorination.

Photochemical Organocatalytic Aerobic Cleavage of C═C Bonds Enabled by Charge-Transfer Complex Formation.

A novel visible-light-driven organocatalytic protocol to access aerobic oxidative cleavage of olefins, promoted by sodium benzene sulfinate, is described herein. An array of alkenes smoothly delivered the corresponding aldehydes and ketones under transition-metal-free conditions. Notably, α-halo-substituted styrenes proceeded with photoinduced oxidation to finally afford α-halo-acetophenones with halogen migration.

Long-term use of combined conventional medicine and Chinese herbal medicine decreases the mortality risk of patients with lung cancer.

Background: We explored the effect of Chinese herbal medicine (CHM) on the long-term survival of lung cancer patients and hazard ratio (HR) and to analyse CHM herbs and formulas for lung cancer treatment.

Methods: We conducted a retrospective cohort study on diagnosed lung cancer patients in 2003-2016 from Taipei and Dalin Tzu Chi General Hospital Cancer Registry Database and from outpatient database from Chinese Medicine and Conventional Medicine Department. We categorised the patients into CHM user and CHM nonuser groups according to the CHM consumption time.

Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records.

Recent studies suggested that Traditional Chinese Medicine could play a beneficial role in conventional cancer treatment. The aim of this retrospective cohort study was to investigate the effect of Chinese herbal medicine (CHM) combined with Western medicine on the survival of patients with colorectal cancer. A retrospective cohort study was conducted on patients with newly diagnosed colorectal cancer identified from the Dalin Tzu Chi Hospital Cancer Registry Database in 2004-2014.

A new cycloartane triterpene glycoside from Souliea vaginata.

A new cycloartane-type triterpene glycoside, namely soulieoside M (1), and one known compound, beesioside I (2), were isolated from the ethanolic extract of the rhizomes of Souliea vaginata. Their structures were determined spectroscopically and compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic activities against three human cancer cell lines.

Evidence for top-down control of eye movements during visual decision making.

Participants' eye movements were monitored while they viewed displays containing 6 exemplars from one of several categories of everyday items (belts, sunglasses, shirts, shoes), with a column of 3 items presented on the left and another column of 3 items presented on the right side of the display. Participants were either required to choose which of the two sets of 3 items was the most expensive (2-AFC) or which of the 6 items was the most expensive (6-AFC). Importantly, the stimulus display, and the relevant stimulus dimension, were held constant across conditions.

A unique cobalt(II)-based molecular magnet constructed of hydroxyl/carboxylate bridges with a 3D pillared-layer motif.

A new pillared-layer coordination polymer, [Co(3)(pybz)(2)(pico)(2)](n) (1; pybz = 4-(pyridin-4-yl)benzoate, pico = 3-hydroxypicolinate), contains rare 2D [Co(3)(pico)(2)](n)(2n+) layers formed by linear cobalt(II) trimers through the unusual mu(4)-kappaN,O:kappaO'-mu(2):kappaO''-mu(2) bridging mode of pico ligands, which are further cross-pillared by exotridentate bridging pybz ligands to form a three-dimensional structure with an unusual uninodal 8-connected body-centered-cubic topology. The bulk magnetic behavior of 1 exhibits ferrimagnetic long-range ordering below 2.6 K, which mainly arises from the cooperative magnetic effect of the intra- and intertrimer arrangements in the 2D magnetic system based on the nature of the exchange modes of mu(2)-hydroxyl, mu(2)-carboxylate oxygen, and 1,1,3-mu(3)-carboxylate bridges.

Magneto-structural correlation in a metamagnetic cobalt(II)-based pillared trilayer motif constructed by mixed pyridyl-type carboxylate ligands.

The first structurally authenticated example of coordinated polymer featuring homometallic pillared-trilayer structure, [Co(3)(ina)(2)(pico)(2)(H(2)O)(2)](n) (1), was built from mixed pyridyl-type monocarboxylates, isonicotinate (ina) and 3-hydroxypicolinate (pico), containing Kagome-type [Co(3)(pico)(2)(H(2)O)(2)](n)(2n+) trilayers. The magnetic phase diagram of 1 shows a metamagnetic transition below 3.2 K, arising from the competing interactions between the antiferromagnetic intralayer couplings in different amplitudes with obviously noncompensated moments versus weak AF interlayer coupling.

Predictors of mortality in hospitalized diabetic patients: A 7-year prospective study.

Unlabelled: This study was conducted to investigate the mortality rate, causes of death, and standardized mortality ratio (SMR), and to identify the significant predictive factors of mortality in diabetic patients at a medical center in Taiwan. Clinical data were obtained from 1792 diabetic inpatients discharged from the metabolism department of a medical center during the years 1996-2002. Underlying causes of death were determined from death certificates.

3D homometallic carboxylate ferrimagnet constructed from a manganese(II) succinate carboxylate layer motif pillared by isonicotinate spacers.

A manganese succinate having a layer structure in which the layers are pillared by the isonicotinate spacers in a 3D architecture exhibits long-range ferrimagnetic order below 5.0 K, with the ferrimagnetism arising, for topological reasons, from the nature of the carboxylate binding modes. The compound is the first structurally authenticated example of a 3D ferrimagnet, featuring a homometallic topological ferrimagnetic sheet among metal carboxylates.