Publications by authors named "Mei-Chin Yang"
Introduction: Sustained lung inflation (SLI) right after birth to decrease the use of mechanical ventilation of preterm infants is controversial because of potential harm. This randomized controlled trial was conducted to evaluate the effectiveness and safety of delayed SLI in neonatal intensive care unit (NICU).
Methods: Preterm neonates requiring continuous positive airway pressure after birth were eligible for enrollment.
Article Synopsis
- - Researchers evaluated the effects and risk factors of high frequency oscillatory ventilation (HFOV) on preterm infants with severe respiratory failure, focusing on those born between 24-34 weeks gestational age, using data from four neonatal intensive care units in Taiwan over a span of eight years.
- - Out of 668 preterm neonates analyzed, a significant majority (56.1%) showed a positive response to HFOV within 3 days, but the overall in-hospital mortality rate was high at 34.7%, with various factors identified as independently associated with mortality.
- - The study suggests that aggressive treatment for conditions like sepsis and preventing organ dysfunction could improve survival outcomes in these vulnerable infants, highlighting the ongoing challenges
High-frequency oscillatory ventilation (HFOV) can be a rescue for neonates with refractory respiratory failure or an early elective therapy for preterm infants with severe respiratory distress syndrome (RDS). However, little is known about the current evolution and therapeutic limitations of HFOV. We therefore aimed to describe its use in clinical practice and predict the risk of mortality for neonates receiving HFOV.
View Article and Find Full Text PDFBackground: Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have not yet been explored.
Methods: A retrospective cohort study was conducted in a tertiary level neonatal intensive care unit (NICU) from 2011 to 2013.
Objectives: The indication of inhaled nitric oxide (iNO) used in preterm infants has not been well defined. Neonates with refractory hypoxemia may benefit from the pulmonary vasodilatory effects of iNO. The aim of this study was to investigate the off-label use of iNO as a rescue therapy.
View Article and Find Full Text PDFBackground: There is a lack of evidence to guide step-wise weaning of positive pressure respiratory support for premature infants. This study sought to compare the efficacy of three weaning protocols we designed to facilitate weaning of very low birth weight (VLBW, less than 1500 g) preterm infants from nasal continuous positive airway pressure (NCPAP) support.
Methods: This was a prospective, randomized, controlled trial of VLBW preterm infants who received positive pressure ventilatory support in our neonatal intensive care unit (NICU) from April 2008 through March 2009.
Article Synopsis
- This study investigates diaphragm atrophy and dysfunction in children undergoing mechanical ventilation, as previous studies primarily focused on adults using ultrasound measurements.* -
- A total of 31 pediatric patients were monitored, with daily ultrasound assessments revealing a significant decline in diaphragm thickness and thickening fraction (DTF) within the first 24 hours of intubation.* -
- Results indicated that a DTF of less than 17% was linked to higher rates of extubation failure, suggesting ultrasound measures could help predict successful extubation outcomes in mechanically ventilated children.*
Objective: To investigate the impact of 1-week ventilator circuit change on ventilator-associated pneumonia and its cost-effectiveness compared with a 2-day change.
Design: An observational cohort study.
Setting: A tertiary level neonatal intensive care unit in a university-affiliated teaching hospital in Taiwan.