Novel Genetic Loci Associated with PhenoAge Acceleration - Changzhou City, Jiangsu Province, China, 2012-2019.

What Is Already Known About This Topic?: China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation.

What Is Added By This Report?: PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations.

Immunoproteomic analysis and identification of possible allergenic proteins in Artemisia annua pollen.

Background: Artemisia annua (A. annua) is a wind-pollinated weed and a major allergen responsible for allergic respiratory diseases in Northern China.

Methods: This study involved the separation of pollen proteins from A.

Transcriptomic Analysis of the CAM Species Under Low- and High-Temperature Regimes.

Temperature stress is one of the major limiting environmental factors that negatively impact global crop yields. is an obligate crassulacean acid metabolism (CAM) plant species, exhibiting much higher water-use efficiency and tolerance to drought and heat stresses than C or C plant species. Previous studies on gene expression responses to low- or high-temperature stress have been focused on C and C plants.

Association between mitophagy and inflammasome in uric acid nephropathy.

Objective: This study was recruited to investigate the role of mitophagy in activating NLRP3 inflammasome in the kidney of uric acid (UA) nephropathy (UAN) rats.

Methods: This study developed a uric acid nephropathy (UAN) rat model divided into five groups: Negative control (NC), UAN model (M), UAN + autophagy inhibitor (3-MA), UAN + lysosome inhibitor (CQ), and ROS scavenger (N-acetylcysteine, N). H&E staining assessed renal structure, ROS levels were measured with 2, 7dichlorofluorescin diacetate, and ELISA measured serum markers (, , cystatin , , , ).

Comprehensive Characterization of Th2/Th17 Cells-Related Gene in Systemic Juvenile Rheumatoid Arthritis: Evidence from Mendelian Randomization and Transcriptome Data Using Multiple Machine Learning Approaches.

Background: Growing research has demonstrated that alterations in Th2 and Th17 cell composition were linked to systemic juvenile rheumatoid arthritis (sJRA). Nevertheless, whether these associations indicate a causal link remains unclear, and the potential effects of Th2/Th17-related molecules have not been clarified.

Methods: Mendelian randomization (MR) alongside transcriptome examination was implemented to ascertain the links between the Th2/Th17 cells and sJRA.

Oral bacteriophage therapy effectively prevent and control of Clostridium perfringens type c infections in newborn piglets.

Clostridium perfringens (C. perfringens) type C exhibits strong pathogenicity, often leading to swine dysentery, severely affecting the economic efficiency of the pig farming industry. Bacteriophages as bacterial viruses have many natural advantages and are potent candidates for controlling bacterial infections.

Diagnosis progress of carcinoma of unknown primary.

Carcinoma of unknown primary (CUP) is a common and complex type of tumor in clinical practice, where the primary site cannot be determined through conventional diagnostic methods, posing significant challenges for clinical diagnosis and treatment. In recent years, advancements in gene expression profiling and genetic testing technologies have provided new perspectives for CUP research, driving progress in this field. By analyzing gene expression profiles, researchers can more effectively identify the tissue origin of tumors, thereby improving diagnostic accuracy.

Co-occurrence of cadmium and ciprofloxacin in environmental media decreases ciprofloxacin degradation by biogenic manganese oxides.

The coexistence of antibiotics with heavy metals is detrimental to humans and the environment. In urban water environments, Cadmium (Cd) and ciprofloxacin (CIP) frequently co-occur. Biogenic manganese oxides (BMOs) are a promising environmental bioremediation material due to their remarkable adsorption and oxidation properties.

Expression of concern: Clicking ferrocene groups to boron-doped diamond electrodes.

Expression of concern for 'Clicking ferrocene groups to boron-doped diamond electrodes' by Manash R. Das , , 2009, 2753-2755, https://doi.org/10.

ZmEREB25 transcription factor mediates transactivation of core starch synthetic genes in maize endosperm via interaction with ZmARF27.

Starch, as the primary storage material in maize endosperm, is essential in determining yield and quality. Although the starch biosynthetic pathway in maize has been well-documented, the transcriptional network underlying endosperm starch synthesis remains elusive. Through a comprehensive co-expression analysis, we screened an endosperm-preferential AP2/ERF transcription factor ZmEREB25, which exhibited a strong correlation with the expression pattern of starch biosynthetic genes in maize endosperm.

A multi-levels analysis to evaluate the toxicity of microplastics on aquatic insects: A case study with damselfly larvae (Ischnura elegans).

Microplastic (MP) pollution prevalent in freshwater environments and jeopardizes the organisms living there. Dozens of studies have been conducted to investigate the harmful effects of microplastics on organisms. However, the most diverse and sensitive aquatic insects are often overlooked, also there is a lack of a comprehensive research exploring the toxicity of microplastics.

Exploring Stakeholder Perspectives on the Transitional Care Needs of Elderly Patients from Hospital to Home: A Phenomenological Study in Shanxi Province, China.

Background: Elderly patients, due to their complex medical conditions and extensive care needs, are at risk of experiencing low-quality or fragmented care during transitions between different healthcare settings. After transitioning from hospital to home, inadequate self-care abilities may result in further health deterioration and increased risks of adverse outcomes. Currently, China lacks effective transitional support services from hospital to home, hindering the smooth transition for elderly patients.

The Environmental Hazards and Treatment of Ship's Domestic Sewage.

With the rapid development of the modern shipping field, the damage caused by ship pollution to the global inland waterways and marine ecosystems has attracted extensive attention from the international community. However, there are fewer reviews on the environmental hazards of domestic ship sewage and its treatment, and a systematic summary of the environmental hazards posed by ship domestic sewage and its treatment is lacking. Based on summarizing the various environmental hazards brought about by a ship's domestic sewage and the corresponding treatment methods, this study elaborates, in detail, on the specific hazards of the main toxic and hazardous substances contained in a ship's domestic sewage on the environment and organisms, and the treatment methods of the ship's domestic sewage and their treatment effects, such as membrane bioreactor (MBR).

A review of hydroxyapatite synthesis for heavy metal adsorption assisted by machine learning.

Heavy metals (HMs) represent a persistent and significant threat to aquatic ecosystems. Hydroxyapatite (HAp) has emerged as a utilized material in the remediation of environmental HMs, owing to its exceptionally high porosity, expansive surface area, and the presence of three-dimensional ordered channels. An in-depth study of the synthesis strategy of HAp and its adsorption properties can help reduce the cost of remediating HMs in aquatic environments and alleviate the water shortage.

Comprehensive effects of tea branch biochar on antibiotic resistance profiles and C/N/S cycling in the compost microbiota of animal manure.

The comprehensive effects of exogenous additives on microbial-driven antibiotic resistance profiles and C/N/S conversion in animal manure composting remains uncertain. This study examined whether tea branch biochar could regulate the microflora involved in antibiotic resistance and C/N/S conversion during pig and chicken manure composting. Compared with the control treatment, biochar addition prolonged the high-temperature period (>55 °C) for 1-2 days and raised the maximum temperature in chicken manure composting.

Association between glucagon-like peptide-1 receptor agonist use and progression of monoclonal gammopathy of uncertain significance to multiple myeloma among patients with diabetes.

Background: In patients with diabetes and monoclonal gammopathy of uncertain significance (MGUS), the impact of glucagon-like peptide-1 (GLP-1) receptor agonists on the natural history of MGUS is unknown. We aimed to assess the association of GLP-1 receptor agonist use in the progression of MGUS to multiple myeloma in patients with diabetes.

Methods: This is a population-based cohort study of veterans diagnosed with MGUS from 2006 to 2021 with a prior diagnosis of diabetes.

[Retracted] Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the BrdU incorporation assay data shown in Fig. 7C were strikingly similar to data that had already appeared in another article written by different authors at different research institutes [Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X and Yue H: Long non‑coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR‑424‑5p/BCL9L axis. Cell Death Dis 12: 72, 2021].

Geographic disparities in primary care physicians: Local impact on long-term outcomes in adult liver transplant recipients.

Background: Geographic inequities are known to affect access to liver transplant (LT); however, the impact of these disparities postoperatively remains unknown. We focus on primary care physicians (PCPs), as frequent managers of long-term LT recipient care.

Methods: Clinical data on adults undergoing liver-only transplant 2010-2021 were obtained from the Organ Procurement and Transplantation Network and linked to zip code-based PCP density and social vulnerability index (SVI) data to quantify the impact of PCP density on graft and overall survival.

Genome-Wide Development and Characterization of Microsatellite Markers in the Great Web-Spinning Sawfly .

The great web-spinning sawfly is notorious for damaging forests across the Palearctic region. At present, uncertainties persist regarding its intraspecies variation and presumed subspecies. To use as tools for future studies, herein we developed genome-wide microsatellite markers for .

Dietary factors and risk for adverse pregnancy outcome: A Mendelian randomization analysis.

This study aims to explore the link between dietary habits and adverse pregnancy outcomes (APOs), including preterm birth (PB), preeclampsia (PE), gestational diabetes mellitus (GDM), fetal growth restriction (FGR), and spontaneous abortion (SA) through two-sample Mendelian randomization (MR). We accessed publicly available genome-wide association studies' (GWAS) summary statistics for dietary habits and APOs, respectively. We used five MR methods to synthesize MR estimates across genetic instruments.