Publications by authors named "Mei Gie Tan"
This study evaluated the performance of a customised Sensititre YeastOne (SYO) plate including isavuconazole (YIT) against existing practice (comprising SYO YO10 plate and isavuconazole gradient strip) in order to streamline the workflow for antifungal susceptibility testing in a tertiary hospital in Singapore. A total of 101 (51 yeasts and 50 moulds) clinical isolates were included for analysis. Isolates included in the study were recovered from a variety of body sites and reflected the case mix encountered in daily practice.
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- The study investigates three unusual isolates of the fungal pathogen Candida auris found in Singapore, aiming to determine if they represent a new and distinct clade from the known clades (I-V).
- Through whole-genome sequencing and antifungal susceptibility testing, researchers found that the isolates were genetically separated from existing clades by a significant number of single nucleotide polymorphisms and had unique genetic characteristics.
- The findings suggest these isolates are a novel clade, referred to as clade VI, highlighting an emerging public health concern due to their resistance patterns and potential for increased transmission.
We report a case of intractable otomycosis with multiple relapses despite conventional topical and systemic antifungal treatment, and adjunctive usage of hyperbaric oxygen therapy. Of note, otomycosis relapsed even after six months of continuous systemic antifungal treatment with therapeutic drug levels and without treatment interruption; and only resolved after application of topical voriconazole. (max.
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