Recent Progress and Advances of Perovskite Crystallization in Carbon-Based Printable Mesoscopic Solar Cells.

Carbon-based printable mesoscopic solar cells (p-MPSCs) offer significant advantages for industrialization due to their simple fabrication process, low cost, and scalability. Recently, the certified power conversion efficiency of p-MPSCs has exceeded 22%, drawing considerable attention from the community. However, the key challenge in improving device performance is achieving uniform and high-quality perovskite crystallization within the mesoporous structure.

Morphological Study on Lenticulostriate Arteries in Patients With Middle Cerebral Artery Stenosis at 7 T MRI.

Background: Middle cerebral artery (MCA) stenosis affects lenticulostriate arteries (LSAs) that supply the basal ganglia. Increased spatial resolution and signal-to-noise ratio of 7 T could facilitate morphological imaging of very-small-diameter LSAs.

Purpose: To evaluate differences in morphological characteristics of LSA among different MCA stenoses.

Enhancing the Performance of Hole-Conductor-Free Printable Mesoscopic Perovskite Solar Cells through Polyaniline-Mediated Iodine Recycling and Defect Passivation.

Printable mesoscopic perovskite solar cells (p-MPSCs) provide an opportunity for low-cost manufacturing of photovoltaics. However, the performance of p-MPSCs is severely compromised by iodine defects. This study presents a strategy by incorporating polyaniline (PANI) to achieve both iodine recycling and iodine defect passivation to significantly improve the performance of p-MPSCs.

Knowledge, attitude, and practice of psoriatic arthritis among patients with psoriasis.

Introduction: This study aimed to investigate the knowledge, attitude and practice (KAP) of psoriatic arthritis among patients with psoriasis. The KAP questionnaire is a widely used tool in public health research, designed to assess individuals' understanding (knowledge), beliefs (attitude), and behaviors (practice) related to a specific health condition.

Methods: A cross-sectional study was conducted at Sinopharm Dongfeng General Hospital from September to November 2023.

Novel chitosan/lignin hydrogel prepared by the Mannich reaction for Pb(II) and Cu(II) removal from aqueous solution.

Green and high-performance biomass-based adsorbents have a good application prospect for the removal of heavy metals. At present, the preparation of chitosan/lignin biomass adsorbents mainly adopts dissolution-drying method, and the obtained adsorbents show relatively poor adsorption performance for heavy metals. To overcome this problem, a novel chitosan/lignin hydrogel (CSL) is prepared by a simple one-pot method through the Mannich reaction.

Melanoma antigen genes (MAGE); novel functional targets in multiple myeloma.

Melanoma Antigen Genes (MAGE) are expressed in a broad range of cancers, including multiple myeloma. MAGE have been under investigation for more than 3 decades as targets for immune therapy, while in parallel, interrogation of their functions has revealed activities that may be particularly critical in multiple myeloma. MAGE-C1 is expressed in about 75% of newly diagnosed cases and this is maintained through the natural history of the disease.

Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variants.

Chimeric antigen receptor (CAR) T cells are a powerful treatment against hematologic cancers. The functional phenotype of a CAR-T cell is influenced by the domains that comprise the synthetic receptor. Typically, the potency of therapeutic CAR-T cell candidates is assessed by preclinical functional assays and mouse models (i.

The role of islet autoantigen-specific T cells in the onset and treatment of type 1 diabetes mellitus.

Type 1 diabetes mellitus (T1DM), a complex chronic disease with an intricate etiology and pathogenesis, involves the recognition of self-antigens by pancreatic islet autoantigen-specific T cells and plays crucial roles in both early- and late-stage destruction of beta cells, thus impacting disease progression. Antigen-specific T cells regulate and execute immune responses by recognizing particular antigens, playing broad roles in the treatment of various diseases. Immunotherapy targeting antigen-specific T cells holds promising potential as a targeted treatment approach.

COVID-19 Vaccine Uptake among People with Spinal Cord Injury and Dysfunction in Ontario, Canada: A Population-Based Retrospective Cohort Study.

Persons with disabilities experience numerous barriers to healthcare access including vaccine accessibility. The purpose of this study was to determine COVID-19 vaccine uptake in the spinal cord injury and disease (SCI/D) population of Ontario and identify potential factors influencing C OVID-19 vaccine uptake. This was a retrospective closed-cohort study using administrative health data on individuals with SCI/D of traumatic and non-traumatic causes to examine the monthly number of COVID-19 vaccine doses received between December 2020 and December 2023.

Advancements in Cardiovascular Disease Research Affected by Smoking.

The harmful substances in tobacco are widely recognized to exert a significant detrimental impact on human health, constituting one of the most substantial global public health threats to date. Tobacco usage also ranks among the principal contributors to cardiovascular ailments, with tobacco being attributed to up to 30% of cardiovascular disease-related deaths in various countries. Cardiovascular disease is influenced by many kinds of pathogenic factors, among them, tobacco usage has led to an increased year by year incidence of cardiovascular disease.

Achievements, challenges, and future prospects for industrialization of perovskite solar cells.

In just over a decade, certified single-junction perovskite solar cells (PSCs) boast an impressive power conversion efficiency (PCE) of 26.1%. Such outstanding performance makes it highly viable for further development.

Expansion and characterization of immune suppressive CD56(bright)Perforin(-) regulatory-like natural killer cells in chronic graft-versus-host disease.

Background: Chronic graft-versus-host disease (cGvHD) is a major cause of morbidity and mortality after Hematopoietic Stem Cell Transplantation (HSCT). Previously, in large patient cohorts, we identified increased numbers of CD56Perforin regulatory-like NK cells (NK-like) associated with cGvHD suppression. Thus, we hypothesized that NK-like cells may be a potential candidate for cGvHD cell therapy.

Exendin-4 intervention attenuates atherosclerosis severity by modulating myeloid-derived suppressor cells and inflammatory cytokines in ApoE mice.

Objective: To investigate the impact of the glucagon-like peptide-1 (GLP-1) receptor agonist Exendin-4 on the proportion of myeloid-derived suppressor cells (MDSCs) in male ApoE mice, and investigate alterations in the concentrations of inflammatory factors in plasma and spleen tissues and assess their correlation with MDSCs.

Methods: Thirty male ApoE mice were randomly divided into five groups (n = 6 per group): control group (CON), model group (MOD), Exendin-4 intervention group (MOD/Ex-4), Exendin-9-39 intervention group (MOD/Ex-9-39), and Exendin-4 + Exendin-9-39 combined intervention group (MOD/Ex-4 + Ex-9-39). After 4 weeks of drug intervention, changes in aortic plaque were observed using Oil Red O staining and H&E staining.

A mega-electron volt emission line in the spectrum of a gamma-ray burst.

A long gamma-ray burst (GRB) is observed when the collapse of a massive star produces an ultrarelativistic outflow pointed toward Earth. Gamma-ray spectra of long GRBs are smooth, typically modeled by joint power-law segments describing a continuum, with no detected spectral lines. We report a significant (>6σ) narrow emission feature at ~10 mega-electron volts (MeV) in the spectrum of the bright GRB 221009A.

Room-Temperature Ripening Enabled by Hygroscopic Salts for Hole-conductor-Free Printable Perovskite Solar Cells with Efficiency Over 20 .

Solution-processed perovskite films generally possess small grain sizes and high density of grain boundaries, which intensify non-radiative recombination of carriers and limit the power conversion efficiency (PCE) of solar cells. In this study, we report the room-temperature ripening enabled by the synergy of hygroscopic salts and moisture in air for efficient hole-conductor-free printable mesoscopic perovskite solar cells (p-MPSCs). Treating perovskite films with proper hygroscopic salts in damp air induces obvious secondary recrystallization, which coarsens the grains size from hundreds of nanometers to several micrometers.

Explainable deep learning and biomechanical modeling for TMJ disorder morphological risk factors.

Clarifying multifactorial musculoskeletal disorder etiologies supports risk analysis, development of targeted prevention, and treatment modalities. Deep learning enables comprehensive risk factor identification through systematic analyses of disease data sets but does not provide sufficient context for mechanistic understanding, limiting clinical applicability for etiological investigations. Conversely, multiscale biomechanical modeling can evaluate mechanistic etiology within the relevant biomechanical and physiological context.

Exploring mood disorders and treatment options using human stem cells.

Despite their global prevalence, the mechanisms for mood disorders like bipolar disorder and major depressive disorder remain largely misunderstood. Mood stabilizers and antidepressants, although useful and effective for some, do not have a high responsiveness rate across those with these conditions. One reason for low responsiveness to these drugs is patient heterogeneity, meaning there is diversity in patient characteristics relating to genetics, etiology, and environment affecting treatment.

Anions Regulation of 1D Perovskite Intrusion-Behavior for Efficient and Stable Perovskite Solar Cells.

Constructing a 1D/3D perovskite heterojunction has recently emerged as a prevalent approach for elevating the efficiency and stability of perovskite solar cells (PSCs), due to the excellent defect-passivation capacity and enhanced resistance to water and oxygen of 1D perovskite. However, the 1D perovskite commonly exhibits much poorer charge carrier transport ability when compared with its 3D counterpart. Tailoring the intrusion depth of a 1D perovskite into the 1D/3D heterojunction is thus of key importance for PSCs but remains a great challenge.

Dual Defect Passivation at the Buried Interface for Printable Mesoscopic Perovskite Solar Cells with Reduced Open-Circuit Voltage Loss.

Numerous defects exist at the buried interface between the perovskite and adjacent electron transport layers in perovskite solar cells, resulting in severe non-radiative recombination and excessive open-circuit voltage (V) loss. Herein, a dual defect passivation strategy utilizing guanidine sulfate (GUASO) as an interface modifier is first reported. On the one hand, the SO preferentially interacts with Pb-related defects, generating water-insoluble lead oxysalts complexes.

Record-Efficiency Printable Hole-Conductor-Free Mesoscopic Perovskite Solar Cells Enabled by the Multifunctional Schiff Base Derivative.

Tailoring multifunctional additives for performing interfacial modifications, improving crystallization, and passivating defects is instrumental for the fabrication of efficient and stable perovskite solar cells (PSCs). Here, a Schiff base derivative, (chloromethylene) dimethyliminium chloride (CDCl), is introduced as an additive to modify the interface between the mesoporous TiO electron transport layer and the MAPbI light absorber during the annealing process. CDCl chemically links to TiO and MAPbI through coordination and hydrogen bonding, respectively, and results in the construction of fast electron extraction channels.