Publications by authors named "Mehwish Wajidi"
Ascorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Article Synopsis
- Photodegradation of drug substances can produce both known and unknown products that interfere with analytical results due to absorption at certain wavelengths.
- The study focuses on improving the accuracy of measurements for methylcobalamin (MC) and hydroxocobalamin by applying linear and non-linear methods to correct for irrelevant absorbances during photolytic degradation involving ascorbic acid (AH).
- Methylcobalamin shows first-order degradation kinetics, with the degradation rate being pH-dependent; it peaks at pH 5.0 when in the presence of ascorbic acid, whereas degradation slows down in more alkaline conditions.
The present research aims to propose a simple and accurate technique for the analysis of Rifaximin in the presence of its stress degradation products and analysis of degradation products by LC-MS/MS analysis. Rifaximin was submitted to forced degradation under the acid hydrolysis condition as prescribed by the ICH. The extract was prepared by firstly treated with HCl and heated about 4 to 8 h.
View Article and Find Full Text PDFIn the present study crude ethanolic extract and its various fractions (ethyl acetate, hexane and aqueous) of medicinal plant Carum carvi L. were examined for α-amylase and α-glucosidase inhibition using an-in vitro model. Both digestive enzymes were extracted from bovine and green gram.
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