Effect of porosity on the structure, mechanical properties and cell viability of new bioceramics as potential bone graft substitutes.

Porous and alternative biografts for possible usages in orthopaedic applications were synthesized by the substitution of gelatin (G), cuttlefish backbone (C), meerschaum sepiolite (S) and hydroxyapatite (H). The effects of different proportions of the Gelatin substitutions on the mechanical properties and structure and cell viability properties of the fabricated biografts were investigated. Throughout the structure and mechanical evaluations, it was found that Gelatin substitution in the fabricated biografts increased the total porosity fraction, particularly for C13G75 and S13G75 biografts.

Synthesizing selenium- and silver-substituted hydroxyapatite-based bone grafts and their effects on antibacterial efficiency and cell viability.

Hydroxyapatite (HA)-based biografts with selenium (Se) and silver (Ag) substitutions were synthesized using the sol-gel method. The synthesized HA-based biografts at various Se and Ag quantity ratios (wt%) were characterized via Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-Ray spectroscopy (EDX). Escherichia coli (JM103) and Gram-positive Staphylococcus aureus (ATCC29293) bacteria were used for the cell viability tests by performing the MTT assay.

Mechanical properties and cell viability of MgO-reinforced biografts fabricated for biomedical applications.

In the present study, biografts were produced by sol gel method by adding different rates of MgO which has bone-like crystal structure and high endurance into different proportions of Ca(NO3)24H2O, KOH, NaNO3, and P2O5 compounds. The biografts were investigated in terms of mechanical and biocompatibility properties. FTIR, SEM and XRD analyses were carried out to examine the chemical characteristics and changes in structural morphology.

CD40, CD45 CTLA-4 levels are elevated in healthy older adults.

Background: The immune system changes with age. In this study we characterized immune changes by performing immunologic screening profiles on ageing individuals.

Methods: This study was performed at Akdeniz University, in the Faculty of Medicine, Department of Immunology.