The effect of hydro-alcoholic extract of on spermatogenesis index in rats treated with cyclophosphamide: An experimental study.

Background: The aim of this study was to investigate the antioxidant effects of extract on improving the toxicity induced by cyclophosphamide (CP) on spermatogenesis. 54 male Wistar rats (4 months old) weighing 200-250 gr were randomly divided into 6 groups (n = 9/each).

Objective: "group 1 (control) underwent the normal diet and water; group 2 (sham) received 2 ml/day normal saline; group 3 (positive control) received 300 mg/kg/day extract; group 4 received extract (300 mg/kg/day) + 5 mg/kg/day CP (Endoxan, baxter oncology gmbh, Germany) after 4 hr; group 5 (CP) received 5 mg/kg/day CP + normal saline 4 hr after it; and group 6 (CP + ) received extract (300 mg/kg/day) 4 hr after 5 mg/kg/day CP.