Publications by authors named "Mehri Shadi"
Article Synopsis
- Psoriasis is an autoimmune skin disease, and Boswellia serrata (BS) gum resin shows potential in managing inflammatory conditions, although its effectiveness is limited due to poor absorption in the body.
- The study tests a new formulation of Boswellia called Boswellia nano emulsion gel (BNG) on mice with dermatitis induced to resemble psoriasis, finding that BNG significantly reduces inflammation and the associated symptoms.
- Results indicated that treatment with BNG lowers gene expression linked to inflammation compared to control groups, suggesting its therapeutic potential, but more clinical studies are needed to confirm these findings in humans.
Background: Moldable hydrogel-based techniques loaded with osteoinductive agents such as metformin have become a promising field for reconstructing critical-sized bone defects, particularly in those with irregular shapes. Here, we used metformin incorporated in an alginate/hydroxyapatite hydrogel to accelerate the repair of the rabbit critical-sized mandibular defect.
Methods: Cytotoxicity and osteoinduction of the metformin-loaded alginate/hydroxyapatite hydrogel were evaluated by culturing the osteosarcoma cell line (MG63).
Article Synopsis
- Tramadol is a widely used opioid pain reliever that affects pain and can also be used for treating depression and anxiety, but it has potential for causing serious damage to areas of the central nervous system (CNS), particularly the hippocampus.
- The study reviewed articles from 2000 to 2022 to assess how tramadol impacts the CNS, revealing processes like cell death and dysfunction that affect neural cell function.
- The findings suggest that tramadol can lead to a significant decrease in neural cell count and volume, potentially causing neuropsychological issues such as memory problems and cognitive deficits, indicating the need for more research on its effects.
Wound healing is a complex process that orchestrates the coordinated action of various cells, cytokines and growth factors. Nanotechnology offers exciting new possibilities for enhancing the healing process by providing novel materials and approaches to deliver bioactive molecules to the wound site. This article elucidates recent advancements in utilizing nanoparticles, nanofibres and nanosheets for wound healing.
View Article and Find Full Text PDFConditioned Media Therapy in Alzheimer's Disease: Current Findings and Future Challenges.
Curr Stem Cell Res Ther
February 2024
Alzheimer's disease (AD) is a neurodegenerative disorder accompanied by a reduction in cognition and memory. Till now, there is no definite cure for AD, although, there are treatments available that may improve some symptoms. Currently, in regenerative medicine stem cells are widely used, mainly for treating neurodegenerative diseases.
View Article and Find Full Text PDFBackground: Tissue engineering focuses on reconstructing the damaged meniscus by mimicking the native meniscus. The application of mechanical loading on chondrocyte-laden decellularized whole meniscus is providing the natural microenvironment. The goal of this study was to evaluate the effects of dynamic compression and shear load on chondrocyte-laden decellularized meniscus.
View Article and Find Full Text PDFCartilage engineering has the potential to overcome clinical deficiency in joint disorders. Decellularized extracellular matrix (dECM) has great biocompatibility and bioactivity and can be considered an appropriate natural scaffold for tissue engineering applications. Both insulin-like growth factor-1 (IGF-1) and mechanical compression stimulate the production of cartilage ECM, modulate mechanical properties, and gene expression.
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