Publications by authors named "Mehrdad Sinaei"
This study evaluated the impact of different acquisition methods, user-directed region of interest placement and post-processing steps on the quantification of dynamic contrast-enhanced ultrasound measurements of blood volume in 29 patients with renal cancer, pre- and post-treatment. Specifically, we compared tumor quantification using multiple planes versus a single plane, breathhold versus free breathing and large region of interest versus a region targeting the area of highest vascularity. Performance was evaluated using area under the receiver operating characteristic curves to identify the method that best predicts progression-free survival.
View Article and Find Full Text PDFBackground: Second-line treatment options in advanced hepatocellular carcinoma (HCC) are limited. Axitinib, a selective potent tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor VEGF) receptors 1, 2, and 3, merits exploration in HCC.
Methods: This was a single-arm phase II trial of axitinib in advanced HCC.
Background: "Waterfall plots" are used to describe changes in tumor size observed in clinical studies. Here we assess criteria for generation of waterfall plots and the impact of measurement error in generating them.
Methods: We reviewed published waterfall plots to investigate variability in criteria used to define them.
Article Synopsis
- - Magnetic resonance (MR) imaging is increasingly preferred for monitoring patients with a history of rectal cancer, aiding in the detection of pelvic recurrence and surgical planning.
- - A study analyzed MR imaging results of 42 patients, revealing that most recurrences occurred around 2.5 years post-surgery, with varied locations including the anastomosis, sidewalls, and pelvic organs.
- - The findings also highlight different recurrence patterns, challenges in recognizing unresectable tumors, and the comparative effectiveness of MR imaging with other diagnostic methods for recurrent rectal cancer.