Publications by authors named "Mehrdad Bayandori"
Article Synopsis
- * A novel nanostructure was created using curcumin-loaded PLGA nanoparticles, which was enhanced with PEI and Bcl-2 siRNA, showing effective cellular uptake confirmed by fluorescence microscopy.
- * Results indicated that this nanoparticle system not only had a high drug encapsulation rate but also significantly increased cytotoxicity against breast cancer cells by lowering Bcl-2 expression by 90.7%.
Neurodegenerative diseases (NDDs) include more than 600 types of nervous system disorders in humans that impact tens of millions of people worldwide. Estimates by the World Health Organization (WHO) suggest NDDs will increase by nearly 50% by 2030. Hence, development of advanced models for research on NDDs is needed to explore new therapeutic strategies and explore the pathogenesis of these disorders.
View Article and Find Full Text PDFGene therapy using clustered regularly interspaced short palindromic repeat plasmids (pCRISPR) reduces mistakes in gene editing and prevents engendering integrational mutagenesis that has been seen in available genome engineering technologies. Developing an ideal and traceable nanocarrier, which can accurately and efficiently transfer this complex into the cytosol and which facilitates the journey towards the nucleus, is a fascinating area of research. Polyethylenimine (PEI) functionalized carbon dots (CD-PEI) were fabricated by one-step microwave assisted pyrolysis with an average size around 3 nm.
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