Immune response evaluation after Sputnik V vaccination in Sari healthcare population.

Background And Objective: Generally, protection against SARS-CoV-2 was assessed by the measurement of antibody titers against spike protein and receptor binding domain "RBD". Many global efforts lead to development of several vaccines based on various strategies. The aim of the present study was to evaluate the efficacy of Sputnik V vaccine among Sari healthcare staff population, Iran.

Improved biological behaviours and osteoinductive capacity of the gelatin nanofibers while composites with GO/MgO.

Among the many polymers introduced for bone tissue engineering, natural polymers have more advantages due to their high biocompatibility and biodegradability, despite their low mechanical properties. Herein, gelatin nanofibers with and without magnesium oxide (MgO) and graphene oxide (GO) nanoparticles were fabricated by electrospinning. The fabricated gelatin and gelatin/GO/MgO nanofibers were examined using scanning electron microscopy, protein adsorption, cell attachment and viability assays.

Identification of β-globin haplotypes linked to sickle hemoglobin (Hb S) alleles in Mazandaran province, Iran.

Carrier frequency of the β allele has been reported to be 0.19% in Mazandaran province, northern Iran. Haplotype analysis of the β allele helps trace the origin of its encoded hemoglobin (Hb) variant, Hb S, in a region.

β-Globin gene cluster haplotypes of Hb D-Los Angeles in Mazandaran Province, Iran.

Several types of hemoglobin D (Hb D) are distinguishable by DNA analysis, and the aim of this study was to identify the types of Hb D variant and β-globin gene haplotypes linked to Hb D in Mazandaran Province, northern Iran. Fifty five individuals were identified as Hb D carriers, and PCR-RFLP analysis revealed that all 55 had the Hb D-Los Angeles type. To identify haplotypes associated with the β(D) allele, family linkage analysis, using the PCR-RFLP method for seven polymorphisms in the β-globin gene cluster, was carried out on families of 23 of these 55 individuals.

Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.

Drug resistance (especially multiple drug resistance) in Mycobacterium tuberculosis makes global concerns in treatment and control of tuberculosis. Rapid diagnosis of drug resistant strains of the bacteria has vital importance in the prognosis of the disease. The aim of this study was to identify the mutations responsible for drug resistance in Mycobacterium tuberculosis strains derived from patients with tuberculosis using line probe assay (LPA) method which rapidly detect drug resistant strains and respective mutations.

Alpha thalassemia gene mutations in neonates from Mazandaran, Iran, 2012.

Aim: Alpha thalassemia is one of the most prevalent disorders worldwide and carrier frequency of the disease is varied in different parts of the world. Although different studies in Iran and Mazandaran province have been carried out to identify different mutations of alpha globin gene among people with low hematological indices, frequencies of these mutations were unknown in general population, and thus the aim of this study was to evaluate the carrier frequencies of alpha globin gene mutations among neonates in Mazandaran.

Material And Methods: Four hundred and twelve neonates were collected from a delivery ward of a hospital in Sari.

Is there any relationship between Le(b) antigen expression and Helicobacter pylori infection?

Introduction: Helicobacter pylori infection is one of the main causes of peptic ulcer. There are some blood groups acting as receptors for the pathogen. Based on this view and previous attempts, we tried to examine the relationship between Lewis blood group and H.