Profiling of five urinary exosomal miRNAs for the differential diagnosis of patients with diabetic kidney disease and focal segmental glomerulosclerosis.

Objective: The objective of this study is to investigate the diagnostic utility of microRNAs (miRNAs) for distinguishing between urine samples from patients with Diabetic Kidney Disease (DKD) and those with Focal Segmental Glomerulosclerosis (FSGS).

Methods: In this multicentric, cross-sectional investigation, we enrolled patients diagnosed with DKD, individuals with primary biopsy-proven FSGS, and healthy controls. The top 5 miRNAs (hsa-mir-21, hsa-mir-30a, hsa-mir-193a, hsa-mir-196a, hsa-mir-200a) were selected to quantify miRNAs in urine samples.

Elastic-plastic finite elements analysis of transient and residual stresses in ceramo-metal restorations.

Transient and residual stresses occurring in partially fixed dental prostheses after the firing process can be calculated with elastic or elastic-plastic finite element analyses (FEA). In this study, firstly, the mechanical and thermal properties at various temperatures of the materials used in a porcelain fused metal (PFM) system were obtained by experimental and literature studies. The effects of viscoelastic and viscoplastic behaviours of the dental porcelain at the elevated temperatures were reflected onto its elastic properties.

Analysis of dentinal stress distribution of maxillary central incisors subjected to various post-and-core applications.

This study evaluated the stress distribution on an endodontically treated maxillary central incisor restored with different post-and-core systems by using a three-dimensional finite element analysis model. Seven three-dimensional finite element models were created. Each model contained cortical bone, cancelous bone, periodontal ligament, 3 mm apical root canal filling, post-and-core and all-ceramic crowns.

The three-dimensional finite element analysis of fixed bridge restoration supported by the combination of teeth and osseointegrated implants.

This study investigated the designs of osseointegrated prostheses in cases of free-end partial edentulism using comparative stress interpreted with the three-dimensional finite element method. Three free-end fixed osseointegrated prostheses models with various connection designs (i.e.

Residual stress effects on fracture energies of cement-bone and cement-implant interfaces.

The effects of residual stresses, which are caused by the temperature difference arising after polymerisation of bone cement, on the fracture energies of cement bone and cement-implant interfaces have been examined by using both experimental and numerical works. Only fracture loads of the test specimen having interfacial cracks have been measured in the experimental stage. The values of fracture loads and temperature difference after polymerisation have been applied to finite element models of the test specimens to calculate critical J-integral values of these both interfaces in the numerical stage.