Publications by authors named "Mehmet Y Oncel"

The concurrent challenges of the COVID-19 pandemic and a significant earthquake in Izmir on October 30, 2020, presented a unique scenario for disaster management and response. This study focuses on the impact of the earthquake, which resulted in 117 fatalities, including 1 due to drowning, and injured 1034 individuals, alongside widespread structural damage including to the Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital. The objective is to assess the activation and implementation of the hospital disaster plan amidst the ongoing pandemic.

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  • The study explored the occurrence and causes of neonatal meningitis across multiple centers in the country, focusing on the risk factors, complications, and outcomes of affected newborns.
  • Out of 634 cases analyzed, the incidence was found to be 2.51 per 1000 ICU admissions, with a notable mortality rate of 23.5%, primarily caused by Gram-positive bacteria, especially coagulase-negative Staphylococci.
  • Key risk factors for increased mortality included respiratory distress requiring ventilatory support, low birth weight, and lack of antenatal steroid exposure, highlighting severe clinical conditions associated with poor outcomes.
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The objective was to apply a population model to describe the time course and variability of serum creatinine (sCr) in (near)term neonates with moderate to severe encephalopathy during and after therapeutic hypothermia (TH). The data consisted of sCr observations up to 10 days of postnatal age in neonates who underwent TH during the first 3 days after birth. Available covariates were birth weight (BWT), gestational age (GA), survival, and acute kidney injury (AKI).

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Introduction: Data on the effectiveness of hydrolyzed infant formula containing both pre- and probiotics (synbiotic formula) on the growth of infants is still scarce. This retrospective study was designed to evaluate the effect of a partially hydrolyzed synbiotic formula on growth parameters and the possible occurrence of major gastrointestinal adverse events or morbidities in infants born via cesarean section (C-section) delivery.

Methods: C-section-delivered term and late preterm infants who received either partially hydrolyzed synbiotic formula, standard formula, or maternal milk and followed at seven different hospitals from five different regions of Turkey, during a 1-year period with a minimum follow-up duration of 3 months were evaluated retrospectively.

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Objective: This study aimed to investigate the characteristics of neonates who were aban- doned in a tertiary maternity hospital and to determine the accompanying morbidities.

Materials And Methods: This hospital-based, retrospective descriptive study was conducted by evaluating the medical records between 2012 and 2019 in a tertiary hospital in İzmir.

Results: During the study period, there were 76 women who left their babies in the hospital following delivery.

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Background: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period.

Methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. Neurodevelopmental outcomes of term neonates operated for MMC and healthy term newborns were compared with the Bayley Scales of Infant and Toddler Development -Third Edition (BSID III) at 12-18 months.

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  • The study aimed to determine if contracting COVID-19 during pregnancy increases the risk of congenital hearing loss in newborns.
  • Utilizing a retrospective cohort design, researchers compared hearing test results of 570 newborns from mothers who had COVID-19 during pregnancy with 570 healthy newborns.
  • Findings indicated a higher rate of hearing loss in the COVID-19 group during the first two tests, suggesting a potential link, though results from the third test showed no significant difference.
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Backround: Aim of the present study is to evaluate the feasibility and reliability of an smartphone application for monitore of bilirubin levels in preterm infants.

Methods: Preterm infants hospitalized in the neonatal intensive care unit with gestational age of<35 weeks were included. Exclusion criteria were parental reluctance and requirement of phototherapy in the last 12 hours.

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  • There is a significant difference in kidney function and injury among neonates with neonatal encephalopathy treated with therapeutic hypothermia, suggesting that traditional definitions of acute kidney injury may miss critical patient-specific information.
  • A study analyzed data from 1,136 neonates undergoing therapeutic hypothermia, revealing an 11.6% incidence of acute kidney injury and a 17% mortality rate, with kidney function metrics being notably higher in those who did not survive.
  • By examining serum creatinine patterns in relation to postnatal age, clinicians can gain better insights into individual kidney functions, leading to more personalized care strategies for these vulnerable patients.
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Patent ductus arteriosus is the most common cardiovascular condition in preterm infants. There is a significant uncertainty about when and how to close ductus arteriosus in preterm infants due to a high spontaneous closure rate even in very immature preterm infants. Diagnosis and management of patent ductus arteriosus remain a challenge for both neonatologists and pediatric cardiologists.

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Unlabelled: The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed.

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Objective: To compare the effectiveness of cycled lighting (CL) or continuous near darkness (CND) on weight in preterm infants.

Study Design: Total 147 infants with a gestational age 25-32 weeks and/or a birth weight 750-1500 g were included in the study. The infants were classified into two groups: CL and CND.

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Background: The aim of the study was to assess the rate of utilization, policy of premedication, technique, equipment, experience on safety and efficacy for less invasive surfactant administration or minimally invasive surfactant therapy (LISA/MIST) use in Turkey.

Methods: An online survey was designed and distributed via Google Forms tool to 350 neonatologists from 173 units through NICU-Turk mailing list of the Turkish Neonatal Society. Participants were asked to answer the survey for their own neonatal intensive care unit (NICU).

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  • The study investigates the clinical characteristics and outcomes of neonates with COVID-19 in Turkey, finding that symptomatic cases often experience respiratory issues.
  • Symptoms commonly included fever, hypoxemia, and cough, with a small percentage requiring mechanical ventilation.
  • High levels of C-reactive protein (CRP) and prothrombin time (PT) were associated with more severe cases, indicating a need for closer monitoring.
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  • * It found that 46% of the infants had moderate-to-large PDA, with 24% managed conservatively and 76% receiving medical treatment, revealing no significant differences in severe complications or surgical needs between the two groups.
  • * Notably, medical treatment raised the risk of mortality but lowered the chances of bronchopulmonary dysplasia (BPD) or death, with ibuprofen and paracetamol being the most common treatments; however, early treatment (before day
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Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey.

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Neuronal ceroid lipofuscinosis (NCL) is a lysosomal storage disorder that causes progressive neurodegenerative disease as a result of storage in neurons and other cells. Late infantile type (NCL Type 2) of NCL, which is the most common neurodegenerative disease in childhood, is characterised by a homozygous mutation in the tripeptidyl peptidase-1 (TPP-1) gene. A male infant was referred to our neonatal intensive care unit (NICU) on 26th day of life with a diagnosis of metabolic disease.

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Objective: Endotracheal intubation is a frequent procedure performed in neonates with respiratory distress. Clinicians use different methods to estimate the intubation insertion depth, but, unfortunately, the improper insertion results are very high. In this study, we aimed to compare the two different methods (Tochen's formula = weight in kilograms + 6 cm; and nasal septum-tragus length [NTL] + 1 cm) used to determine the endotracheal tube (ETT) insertion depth.

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Objective: We aimed to assess the pain perception of preterm infants treated with different surfactant administration techniques by using heart rate variability (HRV).

Methods: Preterm infants who required surfactant therapy for RDS were randomized to INSURE or MIST groups. HRV analysis was performed by Newborn Infant Parasympathetic Evaluation monitor.

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Background: Diagnosis is the most strenuous step in the evaluation of neonatal sepsis. No gold standard diagnostic method is available except for blood culture. We aimed to investigate the role of positive and negative acute phase reactants, namely presepsin and fetuin-A, in the diagnosis of culture-proven late-onset sepsis.

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