Publications by authors named "Mehmet Salih Tuncer"
People with tumours in specific brain sites might face difficulties in tasks with different linguistic material. Previous lesion-symptom mapping studies (VLSM) demonstrated that people with tumours in posterior temporal regions have more severe linguistic impairments. However, to the best of our knowledge, preoperative performance and lesion location on tasks with different linguistic stimuli have not been examined.
View Article and Find Full Text PDFObjective: Surgical resection of gliomas involving the supplementary motor area (SMA) frequently results in SMA syndrome, a symptom complex characterized by transient akinesia and mutism. Because the factors influencing patient functional outcomes after surgery remain elusive, the authors investigated network-based predictors in a multicentric cohort of glioma patients.
Methods: The participants were 50 patients treated for glioma located in the SMA at one of the three centers participating in the study.
Background: Surgical planning with nTMS-based tractography is proven to increase safety during surgery. A preoperative risk stratification model has been published based on the M1 infiltration, RMT ratio, and tumor to corticospinal tract distance (TTD). The correlation of TTD with corticospinal tract to resection cavity distance (TRD) and outcome is needed to further evaluate the validity of the model.
View Article and Find Full Text PDFBackground: The resection of a motor-eloquent glioma should be guided by intraoperative neurophysiological monitoring (IOM) but its interpretation is often difficult and may (unnecessarily) lead to subtotal resection. Navigated transcranial magnetic stimulation (nTMS) combined with diffusion-tensor-imaging (DTI) is able to stratify patients with motor-eloquent lesion preoperatively into high- and low-risk cases with respect to a new motor deficit.
Objective: To analyze to what extent preoperative nTMS motor risk stratification can improve the interpretation of IOM phenomena.
Article Synopsis
- The study focused on the impact of surgical injury to major white matter pathways on language function in patients undergoing glioma surgery.
- It involved 50 patients and utilized advanced imaging techniques to analyze and predict language outcomes based on the condition of five key language tracts.
- Findings showed that damage to specific brain areas significantly increased the risk of persistent language issues post-surgery, indicating that preoperative tractography can help assess aphasia risks for individual patients.