Effect of sevoflurane anesthesia on the severity of renal histopathologic changes in rabbits pretreated with gentamicin: A controlled, investigator-blinded, experimental study.

Background: Inorganic fluoride and compound A are potential nephrotoxic products of sevoflurane, a halogenated inhalational general-anesthetic drug.

Objective: The aim of this study was to microscopically examine the effect of sevoflurane on the severity of renal histopathologic changes in rabbits pretreated with gentamicin.

Methods: In this controlled, investigator-blinded, experimental study at the Firat University School of Medicine, Elazig, Turkey, male New Zealand white rabbits (age range, 6-8 months; weight range, 2600-3400 g) were randomly divided into 4 groups of equal size.