The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats.

Purpose: Warm-ischemia-induced injuries might be encountered during renal transplants from cadavers and healthy donors. Toll-like receptors (TLR) in ischemia-reperfusion (I/R) injury are one of the indicators of intracellular injury pathways. The intensity of ischemic injury is directly proportionate to high TLR levels.