Publications by authors named "Mehmet Isik"

Article Synopsis
  • The Intermountain Risk Score (IMRS) is a simple and inexpensive tool that predicts mortality using patient demographics and basic lab results, specifically for those with acute pulmonary edema.
  • In a study of 371 patients, the IMRS effectively stratified patients into low, moderate, and high-risk groups based on their likelihood of dying within one month or one year of hospitalization.
  • Results showed that a cutoff IMRS value of 15.5 significantly predicted mortality risk, with higher scores correlating to greater risk of death, confirming the IMRS as a reliable predictor in this medical context.
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  • A gram-negative bacterium typically does not cause infective endocarditis, but a rare case has been documented.
  • In this case, after an eight-year period following the Benthall-DeBono procedure, there was late dehiscence of an aortic valve conduit due to leakage.
  • This led to the development of a large pseudoaneurysm and severe paravalvular aortic insufficiency, ultimately linked to the infective endocarditis infection.
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Background: Primary cardiac tumors are uncommon, with approximately 70-80% classified as benign. Myxomas constitute roughly half of all benign cardiac tumors, while cardiac hydatid cysts are exceptionally rare. Shortness of breath is a prominent symptom associated with these conditions.

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  • The study compares outcomes of tricuspid valve surgery performed on a beating heart versus an arrested heart, analyzing data from 204 patients over five years.
  • Patients were divided into two groups, with 103 undergoing surgery using cross-clamping and 101 using a beating-heart technique, while also receiving other cardiac interventions as needed.
  • Results showed that the beating-heart group had shorter recovery times, lower rates of re-exploration and mortality, and improved echocardiography findings at six months post-surgery, suggesting this method is preferable to avoid clamp-induced ischemia.
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The prediction of patient survival is crucial for guiding the treatment process in healthcare. Healthcare professionals rely on analyzing patients' clinical characteristics and findings to determine treatment plans, making accurate predictions essential for efficient resource utilization and optimal patient support during recovery. In this study, a hybrid architecture combining Stacked AutoEncoders, Particle Swarm Optimization, and the Softmax Classifier was developed for predicting patient survival.

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Objective:  The possible relationships between the histopathological findings of carotid body tumors and age, gender, tumor diameter, and Shamblin classification were investigated. In addition, preoperative embolization status, development of neurological complications, need for vascular reconstruction, hemoglobin change, and discharge time were examined and the effects of these variables on each other were analyzed.

Methods:  Between 2008 and 2022, 46 cases who underwent carotid body tumor excision were examined retrospectively.

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Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%.

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Objectives: This study aimed to determine the normative values of the functional head impulse test (fHIT) test in healthy young adults.

Materials And Methods: The study included 100 individuals, 58 females and 42 males, aged 20-25 years. Beon Solution Zero Branco (TV) fHIT test was applied to all participants.

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  • Doctors studied patients who had cataract surgery during the COVID-19 pandemic to see how well it went and if they were happy afterward.
  • Most patients had no problems during surgery, and everyone had good vision after it, with many feeling satisfied a month later.
  • This method of doing surgery on both eyes at once is helpful during the pandemic because it means fewer hospital visits, especially for older people and those with other health issues.
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Objective: The aim of this study was to investigate postoperative left ventricular changes [left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), patient-prosthesis mismatch (PPM), pulmonary artery pressure (PAP), gradients, and ejection fraction (EF)] according to the valve type used in patients undergoing aortic valve replacement (AVR) due to isolated aortic stenosis.

Methods: A total of 199 patients with isolated AVR due to aortic stenosis between 2010 and 2020 was retrospectively investigated. Four groups were identified according to the valve type used (mechanical, bovine pericardium, porcine and sutureless).

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Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections.

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  • Infections of cardiovascular implantable electronic devices (CIED) are primarily caused by Gram-positive bacteria, but this study focuses on the less common Gram-negative bacteria (GNB) infections, aiming to understand their risk factors, clinical features, and outcomes.
  • The study analyzed data from 236 patients across 17 European centers, comparing 59 patients with GNB-CIED infections to controls with Gram-positive infections and those without infections, finding no major differences in clinical presentation but notable trends in diagnostic imaging.
  • Key risk factors for GNB infections included obesity, a high comorbidity index, specific pacemaker settings, and the right subclavian vein site for device implantation; these infections were also linked to higher mortality rates, suggesting
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Objective: This study aimed to evaluate bloodstream infections caused by in immunocompetent patients with respect to clinical features and risk factors for mortality.

Methods: We reviewed bloodstream infections detected between January 1, 2012, and July 1, 2021, to identify nosocomial bacteremia in Koşuyolu Research and Training Hospital.

Results: We identified a total of 97 patients with bloodstream infections.

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Objective: Multidisciplinary patient blood management practices reduce costs of blood products and transfusion-related complications in hospitals. Hospital costs are high in pediatric cardiac surgery patients because high hematocrit levels are usually needed; the need for blood products is high due to complex and long surgical procedures; the length of stay in the intensive care unit (ICU) is long, and the use of treatment modalities such as dialysis and ECMO is common in this patient population.

Methods: In this retrospective study, we investigated the effects of the use of the multidisciplinary patient blood management protocols on the use of blood products and associated costs by comparing the outcomes of the protocol implemented in the year 2019 to the blood product use and costs of the previous year.

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Introduction: Although vaccines are the safest and most effective means to prevent and control infectious diseases, the increasing rate of vaccine hesitancy and refusal (VHR) has become a worldwide concern. We aimed to find opinions of parents on vaccinating their children and contribute to available literature in order to support the fight against vaccine refusal by investigating the reasons for VHR on a global scale.

Methodology: In this international cross-sectional multicenter study conducted by the Infectious Diseases International Research Initiative (ID-IRI), a questionnaire consisting of 20 questions was used to determine parents' attitudes towards vaccination of their children.

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Introduction: The coronavirus disease 2019 (COVID-19) pandemic has required changes in the management of pediatric cardiac surgery. We would like to share the patient treatment and surgical management strategies employed in our Pediatric Cardiovascular Surgery Clinic during the COVID-19 pandemic.

Methods: A total of 112 patients were followed up in our clinic between 11.

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Clays, glucomannans and their combinations are widely used to bind mycotoxins in contaminated feeds to reduce their toxic effects on animals. In the present study, the binding abilities of clinoptilolite, sepiolite, bentonite, and montmorillonite, glucomannan, and four commercial TB products (P1, P2, C1 and C2) were investigated in vitro for their binding effects on seven different mycotoxins (AF, aflatoxin; OTA, ochratoxin; ZEA, zearalenone; DON, deoxynivalenol; FUM, fumonisin; T-2 toxin, and HT-2 toxin) in medium at pH 3.0 and 6.

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Aim: We investigated the risk of increased nosocomial infections and the associated pathogens in patients who underwent paediatric cardiovascular surgery and were put on extracorporeal membrane oxygenation support. We studied the duration of extracorporeal membrane oxygenation use and other variables that may be associated with increased nosocomial infection risk.

Methods: Patients who were treated with an extracorporeal membrane oxygenation in paediatric cardiovascular surgery ICU between 2010 and 2020 were included in this retrospective study.

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Objective: The aim of the present study was to share the experiences gained from emergency and semiemergency cases of open heart surgery performed during the COVID-19 outbreak in Necmettin Erbakan University Meram Medical Faculty Hospital, which was defined as a pandemic hospital by Turkish Ministry of Health and provided third degree health services.

Materials And Methods: A total of 54 patients were retrospectively analyzed between 23 March and 22 May 2020, who were diagnosed to have aortic dissection, coronary artery disease, and heart valve diseases.

Results: Thirty-two CABG, 12 valve surgery, 6 aortic surgery, 4 CABG + valve surgeries were performed.

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Objective: The aim of this study was to contribute to the issue of "Who should we perform Doppler ultrasonography on?" and determine the contribution of comorbid diseases to the development of carotid artery stenosis (CAS) and preoperative CAS by examining comorbid diseases in patients undergoing coronary artery bypass graft operation (CABG) and also discussing the effect of carotid stenosis levels on postoperative stroke.

Method: Between 2011-2015, a total of 921 patients who underwent cardiac surgery retrospectively were examined. Of these, 594 CABG patients aged 60 and over who underwent preoperative carotid Doppler examination were analyzed.

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Aim: The aim is to discuss the clinical characteristics, time, anatomical vascular distribution, radiological features, functional outcomes after stroke and possible pathophysiological mechanisms of acute ischemic stroke (AIS) that develop after cardiac surgery.

Method: A total of 3,474 patients, who underwent cardiac surgery between 2015-2020, retrospectively were analyzed. Forty-nine patients, who developed AIS and had brain CT and diffusion MR images during hospitalization, were included in the study.

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Other markers investigated in this population have gained importance in the diagnosis of the disease since the course of COVID-19 disease is atypical in the paediatric population and PCR may be misleading. The leukocyte profile is one of these biochemical tests. Children did not have lymphopenia in hemogram count, whereas relatively neutropenia and monocytosis were detected, unlike the adult population.

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Cardiac haemangiomas are rare cases and can be seen at any age of life. A 49-year-old woman was admitted to our hospital with chest pain. A well-circumscribed soft tissue mass extending from the pulmonary artery truncus to the left ventricular inferior neighborhood.

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A 55-year-old man who underwent bicaval orthotopic heart transplantation nine months earlier presented with complaints of diarrhea and oliguria. Laboratory findings showed pancytopenia and an elevated creatinine level. Cyclosporine and mycophenolate mofetil were discontinued, and the patient received only everolimus.

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Objective: Volumetric changes in the aneurysm sac were evaluated following endovascular aortic repair (EVAR) in intact abdominal aortic aneurysm (AAA) patients who underwent EVAR.

Methods: Fifty-two patients, who underwent EVAR from 2015 to 2019, were analysed retrospectively. A total of 158 computed tomography angiography scans was examined by performing reconsctructive volumetric calculations.

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