Publications by authors named "Mehmet E Duru"

The current study aims to prepare a green extract using a new method in addition to conventional extraction methods including; methanolic and ultrasonic extraction of , to compare their phenolic composition utilizing high-performance liquid chromatograph equipped with a diode array detector (HPLC-DAD), anti-bacterial, anti-oxidant, and enzyme inhibition activities. The results of HPLC-DAD analysis showed that Rosmarinic acid was found the highest amount in the methanolic extract followed by ultrasonic and green extracts as 169.7 ± 0.

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  • - Mushrooms are nutritious with high protein and healthy fats, and they are being researched for their health benefits and potential industrial applications, particularly their natural compounds.
  • - The study explored the cytotoxic effects of different extracts from the mushroom on various cancer cell lines using various scientific assays, finding that the hexane extract was most effective against A549 cells, while methanol extract showed considerable efficacy against PC-3 cells.
  • - Additionally, the methanol extract exhibited strong antioxidant activity and reduced inflammatory markers (like TNF-α and VEGF), while the hexane extract displayed notable antimicrobial properties against several pathogens.
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  • The research focuses on the benefits of natural product-based therapies, particularly emphasizing the healthful properties of a common spice used in Algeria, (L.) Ach., through various extract evaluations.
  • Key findings revealed the presence of significant phenolic compounds such as rosmarinic acid and caffeic acid, alongside strong antioxidant and anti-inflammatory activities linked to both aqueous and methanolic extracts.
  • The methanolic extract demonstrated notable cytotoxic effects on human cancer cells while showing no harm to non-tumor cells, suggesting its potential as a natural therapeutic agent.
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  • Alzheimer's disease and diabetes impact global health, with specific enzymes targeted for treatment: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) for AD, and α-amylase, α-glucosidase for diabetes.
  • A study isolated various compounds from a medicinal plant, identifying several derivatives of ellagic acid that showed moderate to strong inhibition of AChE and BChE, with 3,3'-di-O-methyl ellagic acid being the most potent.
  • In addition, some compounds effectively inhibited α-amylase and α-glucosidase, outperforming acarbose, indicating their potential as therapeutic agents for diabetes management.
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In recent years, there have been an attempt to develop safe and environmental friendly solvents to replace conventional solvents, and use for extraction bioactive compounds from natural sources. A current investigation involved the preparation of green, methanolic, and ultrasonic extracts of S. sclarea, and compared their phenolic profiling using HPLC-DAD, antibacterial, antioxidant, and enzyme inhibition activities.

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is a medicinal vegetable used in seasoning desserts, juices, and beverages. An evaluation of the total flavonoid, phenolic, tannin and anthocyanin contents indicated that these classes of compounds are distributed variably in the different fractions. In summary, the HPLC-DAD analyses enabled the identification and quantification of thirteen phenolic compounds in an ethyl acetate extract (EAE), nine in a dichloromethane extract (DCME), seven in an aqueous extract (AQE) and four in a butanol extract (BE).

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Edible mushrooms are important providers of nutrients and are well recognized for their particular organoleptic properties. The volatiles that releases serve purposes beyond simply appealing to our sense of smell. Truffles have different smells and tastes due to the fact that they contain different volatile components; therefore, aroma is essential in defining the organoleptic properties and quality of truffles.

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The objectives of the present study are to compare the phenolic profiles and biological activities of 15 citrus honey samples from three different locations in Turkey using a chemometric approach. The HPLC-DAD analysis was used to determine phenolic profiles. Nineteen phenolic compounds were identified.

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is an edible mushroom from the matsutake group growing under Cedar trees. Bioactivity-guided fractionation of afforded two new ( and ), three known ergosterols (-), and four known (-) compounds. Structures were identified as anatoluin A (), anatoluin B (), 5,6-epoxy-ergosta-7,22-dien,3-ol (), ergosterol-endoperoxide (), ergosterol,3-ol (), 3,5-dihydroxyfuran-2(5)-one (), mannitol (), turanose (), fumaric acid () using spectroscopic techniques.

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Present study aimed to establish the stimulatory effects of bee drone larvae (BDL) on the androgenic effects and growth performance of goat male kids (GMK). The effects of BDL on growth and testosterone hormone levels were investigated in Saanen male kids. A total of 26 Saanen male kids (13 heads control, 13 heads treatment groups) were used for determining the effects of BDL 60 days after the weaning period.

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In this work, in order to explore a new Algerian medicinal plant used in traditional medicine, the essential oil of the leaves of L. (Apiaceae) collected from Algeria, obtained by hydrodistillation, was analyzed by GC/MS. Thirty-two compounds were identified accounting for 98.

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Isolation and bioactive effects of the roots of L. were firstly investigated herein. Enzyme (acetylcholinesterase, butyrylcholinesterase, urease, α-amylase, α-glucosidase, and tyrosinase) inhibitory effects of root extracts were tested.

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  • The study examined antioxidant and enzyme inhibitory activities of hexane and methanol extracts from various mushrooms, with implications for common human diseases.
  • Methanol extract showed the strongest antioxidant activity in multiple assays, while hexane extract was most effective in inhibiting certain enzymes like AChE and BChE.
  • Gallic acid was identified as a prevalent phenolic compound across the mushrooms, suggesting potential for these fungi in developing natural treatments for oxidative stress, diabetes, and neurological issues.
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Food pathogens represent an important health threat, and it is relevant to study the effect of foodstuffs such as spices which can inhibit bacterial growth. This study reports the antimicrobial, antibiofilm, and enzyme (Acetylcholinesterase, Butyrylcholinesterase, urease, tyrosinase) inhibitory activities of two medicinal food spices belonging to the Annonaceae family, and . GC-MS (gas chromatography mass spectrometry) analysis of silylated samples of Methanol-Dicloromethane (50:50) extracts of both plants led to the identification of nine compounds in and seven compounds in .

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  • Polysaccharides from mushrooms play a crucial role in their biological activities, with two new types (Galactomannan I and II) isolated from specific mushroom species.
  • The structures of these galactomannans were identified using advanced techniques, showing a composition of D-mannose and D-galactose and specific molecular weights.
  • Testing revealed that Galactomannan II has significant anticholinesterase activity, making it a potential natural agent for treating conditions related to cholinesterase enzymes, despite having low antioxidant activity.
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The increasing resistance of bacteria to antibiotics has motivated the interest in potent natural compounds capable of disrupting bacterial cell-to-cell communication. Column chromatography of seed extract of Annona senegalensis afforded N-cerotoyltryptamine (1), asimicin (2) and ent-19-carbomethoxykauran-17-oic acid (3). The compounds were tested for their antimicrobial, antibiofilm, and anti-quorum sensing activities.

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In this study, urease, tyrosinase, cholinesterase inhibitory, and antioxidant activities of various extracts of Sideritis albiflora and Sideritis leptoclada were determined together with the phytochemical contents. In addition, the fatty acid compositions and phenolic compounds were investigated by gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS), and high performance liquid chromatography-diode array detector (HPLC-DAD). Rosmarinic acid and caffeic acid in both Sideritis species were identified as the most abundant phenolic compounds whereas palmitic acid was found as a major fatty acid.

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Chromatographic purification of Fuscoporia torulosa extracts resulted in the isolation and characterization of a new steroid, 5α,8α-epidioxyergosta-6,22-dien-3β-il-palmitate (1) and 10 known compounds (2-11). The structures of compounds were elucidated by IR, NMR, MS analyses, and comparison with literature data. Cytotoxic activities against MCF-7 (breast cancer), PC-3 (prostate cancer), and 3T3 (nontumor) of the extracts and cytotoxic, antioxidant, cholinesterase, and tyrosinase inhibitory activities of all isolated compounds were evaluated.

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Chemical composition and structural characterization of polysaccharides of Fomes fomentarius (FF), Fuscoporia torulosa, Ganoderma adspersum, Ganoderma applanatum (GAP), Ganoderma lucidum, Phellinus igniarius, Pleurotus ostreatus (PO), and Porodaedalea pini (PP) tree mushrooms with antioxidant and anticholinesterase activities were determined in this research. Total carbohydrate contents of the polysaccharides were ranged between 65.06 ± 6.

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Recently, mushroom species have been the focus of researchers' interest because of several bioactivities. The aim of this study was to investigate the chemical profile and biological activities of various extracts of two Stereum species (S. rugosum and S.

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Anthemis species are traditionally used to treat infectious and inflammatory processes, among others clinical disturbances. In the current study, the chemical composition, the total phenolic and flavonoid contents, the antioxidant, anticholinesterase, antimicrobial, and antibiofilm activities of Anthemis stiparum subsp. sabulicola aerial parts methanolic extract (As-ME) and essential oil (As-EO) were investigated.

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Objectives: To assess current iodine levels and related factors among healthy pregnant women. 

Methods: In this cross-sectional, hospital-based study, healthy pregnant women (n=135) were scanned for thyroid volume, provided urine samples for urinary iodine concentration and completed a questionnaire including sociodemographic characteristics and dietary habits targeted for iodine consumption at the Department of Obstetrics and Gynecology, School of Medicine,Muğla Sıtkı Koçman University, Muğla, Turkey, between August 2014 and February 2015. Sociodemographic data were analyzed by simple descriptive statistics.

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Phytochemical investigation of the Rhizopogon luteolus Fr. led to the isolation of one new fatty acid ester, 3-hydroxy-2,4-dimethylheptacosyl acetate (1) together with two known compounds tetracosanoic acid (2) and ergosterol (3). 1D and 2D NMR, and MS techniques were used for structural elucidation.

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