Publications by authors named "Mehmet Dogan Asik"
Understanding the molecular mechanisms and gene expression in laryngeal squamous cell carcinoma (LSCC) may explain its aggressive biological behavior and regional metastasis pathways. In the present study, patients with locally advanced LSCC tumors were examined for differential gene expression in the normal mucosa (non-tumoral mucosa), tumors and lymph node tissues. The aim was to identify possible predictive genes for lymph node metastasis.
View Article and Find Full Text PDFArticle Synopsis
- - Decellularization is a promising technique in tissue engineering that uses natural materials to create 3D structures mimicking the biomechanical properties of target tissues, offering advantages over synthetic materials.
- - Amniotic membranes, which support embryos during pregnancy, have potential for tissue regeneration but are limited by their thinness; researchers developed a method to create multilayered tissue constructs using decellularized amniotic membranes from rats.
- - The study tested various decellularization methods (physical and chemical) and found that the most effective methods involved a combination of UV exposure and freezing techniques alongside hypertonic solutions and sodium dodecyl sulfate, particularly in groups F and G.
In recent years, there has been an increase in nanoparticle research towards creating better release systems that can maintains the effective dosage over desired periods. Conventional nanoparticle systems have not been successful for this goal. Thus, the aim of this study is to evaluate the sequential release profiles of hybrid materials, combining nanoparticles, hydrogels and bone cement, for the treatment of arthroplasty infections.
View Article and Find Full Text PDFBackground: Chondral injury is a common problem around the world. Currently, there are several treatment strategies for these types of injuries. The possible complications and problems associated with conventional techniques lead us to investigate a minimally invasive and biotechnological alternative treatment.
View Article and Find Full Text PDFAim: A limited healing response to focal cartilage lesions is frequently encountered in the clinical cartilage pathology. This study compares the gene expression patterns of damaged and undamaged regions of cartilage obtained from the same patient with focal cartilage lesions. The aim of this study is to provide new genes and proteins, which may be a potential future target of research.
View Article and Find Full Text PDF: The aim of this study was to synthesize bevacizumab-loaded nanoparticles and evaluate their effects on the treatment of posterior segment diseases via subtenon injections. : Bevacizumab-loaded chitosan nanoparticles (BLCNs) were synthesized by the ionic gelation method, and their physicochemical characteristics and release profile were studied. The BLCNs were characterized using atomic force microscopy (AFM), FTIR spectroscopy, dynamic light scattering, and scanning electron microscopy.
View Article and Find Full Text PDFPurpose: To evaluate the role of sex steroid hormone receptors in corneal epithelium in etiopathogenesis of keratoconus (KC).
Methods: Thirty patients with KC who were planned for corneal collagen-crosslinking and 20 patients who were planned for excimer laser for refractive errors included in this study. Corneal epitheliums were curated mechanically during surgeries.
A new device was tested on rabbits for the improvement of lagophthalmos, which causes dryness and irritation of the eye and may cause blindness if untreated. In the presented study, 14 rabbits were injected with local anesthetic to induce temporary facial palsy leading to lagophthalmos on one side. To provide functionality to the upper eyelids, ferromagnetic steel plates were either implanted within the eyelid or taped on the eyelid surface.
View Article and Find Full Text PDFPurpose: To evaluate the oxidative stress status and anti-oxidative defence in patients with age-related macular degeneration (AMD).
Methods: A total of 22 patients diagnosed with AMD and 23 age-matched healthy controls were included in the present study. Serum levels of total oxidant status (TOS), total antioxidant status (TAS), total thiol status (TTS) and paraoxonase 1 (PON1) activity were investigated from samples.