Chronic rhinosinusitis (CRS) is linked to increased risks of developing anxiety and depression, but the role of socioeconomic factors in this relationship has not been fully studied.
A retrospective cohort study utilized the National Institutes of Health All of Us database, analyzing over 33,000 adult patients to examine the bidirectional risk of anxiety and depression in patients with CRS, with up to 5 matched controls without CRS.
Results indicated that patients with CRS had significantly higher odds (4.39 times) of having anxiety and 2.04 times for depression, along with a greater risk of developing these conditions compared to non-CRS controls after their CRS was diagnosed.