White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Excessive Daytime Sleepiness.

Excessive daytime sleepiness (EDS) is relatively frequent in patients with Parkinson's disease (PD), having a prominent burden on patients' quality of life and causing dangerous events such as motor-vehicle accidents. Previous studies have indicated the role of certain neural tracts in the pathophysiology of sleep disturbances, especially in PD patients. We hypothesized that white matter integrity and connectivity might be altered in patients with PD and EDS.

Serum Insulin-Like Growth Factor-1 in Parkinson's Disease; Study of Cerebrospinal Fluid Biomarkers and White Matter Microstructure.

Growing evidence shows that impaired signaling of Insulin-like Growth Factor-1 (IGF-1) is associated with neurodegenerative disorders, such as Parkinson's disease (PD). However, there is still controversy regarding its proinflammatory or neuroprotective function. In an attempt to elucidate the contribution of IGF-1 in PD, we aimed to discover the relation between serum IGF-1 levels in drug-naïve early PD patients and cerebrospinal fluid (CSF) biomarkers as well as microstructural changes in brain white matter.

The effect of occupational noise exposure on systolic blood pressure, diastolic blood pressure and salivary cortisol level among automotive assembly workers.

. Both auditory and non-auditory health can be affected by exposure to occupational noise. The aim of this study was to evaluate the association of high occupational noise (at three levels) with systolic blood pressure (SBP), diastolic blood pressure (DBP) and salivary cortisol concentration in an automotive factory.

Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies.

Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms. One of the white matter tracts shown to be disrupted in PD with a possible contribution to some PD symptoms is the inferior longitudinal fasciculus (ILF).

Capturing Bone Signal in MRI of Pelvis, as a Large FOV Region, Using TWIST Sequence and Generating a 5-Class Attenuation Map for Prostate PET/MRI Imaging.

Purpose: Prostate imaging is a major application of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI). Currently, MRI-based attenuation correction (MRAC) for whole-body PET/MRI in which the bony structures are ignored is the main obstacle to successful implementation of the hybrid modality in the clinical work flow. Ultrashort echo time sequence captures bone signal but needs specific hardware-software and is challenging in large field of view (FOV) regions, such as pelvis.