Publications by authors named "Mehdi Shafieeardestani"
Background: Lately, the employment of nano-carriers has been known as an optimistic means of drug and vaccine delivery.
Objective: Nano vaccines are a novel tier of vaccines that can develop humoral and cellular immune responses and can be introduced as a practical and secure nano vaccine candidate for the prevention of diseases. The purpose of this study was to accomplish and use biodegradable nano-carriers for the synthesis of pentavalent vaccine and immunogenicity evaluation in the animal models.
Background: Pseudomonas aeruginosa has an important role in nosocomial infections.
Objective: To evaluate biological activity of the detoxified LPS (D-LPS) entrapped into Poly lactic-co-glycolic acid (PLGA) nanoparticles.
Materials: LPS was extracted and detoxified from the P.
Article Synopsis
- A new compound called DOTA-conjugated alendronate (DOTA-ALN) was developed as a potential bone-targeting agent using gallium-68 for imaging.
- After synthesizing DOTA-ALN, researchers performed various tests on rats to evaluate its stability, binding to bone-like material, and how it distributed in the body.
- The results showed that while DOTA-ALN had high purity and stability, it was mainly excreted through the kidneys and did not effectively bind to bone, limiting its usefulness for bone imaging.
Pseudomonas aeruginosa is a major cause of respiratory tract infections worldwide, particularly in hospitalized patients with immunosuppressed conditions and cystic fibrosis (CF). Excessive use of antibiotics means that there is currently resistance among bacterial infections to many drugs. Vaccination is a strategy that can reduce mortality and morbidity rates in infections such as those caused by P.
View Article and Find Full Text PDFObjective: To find out whether DTPA-DG complex can enhance clearance of intracellular free iron.
Materials And Methods: Diethylenetriaminepentaacetic acid-D-deoxy-glucosamine (DTPA-DG) was synthesized and examined for its activity as a cell-permeable iron chelator in human hepatocellular carcinoma (HEPG2) cell line exposed to high concentration of iron sulfate and compared with deferoxamine (DFO), a prototype iron chelator. The effect of DTPA-DG on cell viability was monitored using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide MTT assay as well.
Article Synopsis
- Major thalassemia leads to iron overload due to frequent blood transfusions, requiring effective iron chelation therapy.
- Current treatments, like deferoxamine and deferasirox, have side effects, prompting research into ciprofloxacin as an alternative chelator.
- The study found that ciprofloxacin significantly reduced iron levels in the liver and heart of rats, suggesting it could improve treatment compliance and life expectancy for thalassemia patients.