Long term effects of gamma radiation on inflammatory and apoptotic biomarkers in nuclear medicine staff.

Background: Gamma radiation at low doses might have potential health effects in long-term exposure. The current study was aimed to search cell death pathway and inflammatory biomarkers in nuclear medicine workers with long-term exposure to gamma radiation.

Material And Methods: Fifty cases with a history of 10 years' exposure to gamma radiation and 30 normal individuals were included in the current study.

Therapeutic Effects of Low-Level Laser Therapy on Pain and Disability of Patients with Failed Back Surgery Syndrome.

Purpose: This study intended to evaluate the effects of Low-Level Laser Therapy (LLLT) on Failed Back Surgery Syndrome (FBSS). FBSS refers to symptoms and disabilities which remain or occur after lumbar spinal surgery. Prevalent treatments for FBSS are based mostly on conservative management while LLLT has gained significant interest in the treatment of a wide variety of musculoskeletal disorders.

Comparison of normal tissue doses in deep inspiration breath-hold and free breathing methods for radiotherapy of left-sided breast cancer using 4D-XCAT digital phantom.

Purpose: To evaluate normal lung and heart tissue doses for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (FB) as a function of breast size and diaphragm displacement using 4D-XCAT digital phantom in a simulation study.

Materials And Methods: 4D-XCAT digital phantom was used to create 36 left-sided breast cancer digital phantom datasets with different breast height (BH) of 40, 50, and 60 mm, breast length (BL) of 16, 17, and 18 mm, and diaphragm excursion of 20, 25, 30, and 35 mm. For each dataset, DIBH and FB treatment plans were prepared using planning computerized radiotherapy-three dimensional (PCRT-3D) treatment planning system (TPS) with superposition computational algorithm.

Evaluation of Anticancer and Cytotoxic Effects of Genistein on PC3 Prostate Cell Line under Three-Dimensional Culture Medium.

Background: Prostate cancer is a major cause of disease and mortality among men. Genistein (GNT) is an isoflavone found naturally in legumes. Isoflavones, a subset of phytoestrogens, are structurally similar to mammalian estrogens.

Combined Effect of Neutron Radiation and Curcumin on Breast Cancer Cells Cytotoxicity in 3D Culture Medium.

Introduction: Introduction: Chemotherapy, biotherapy, and radiotherapy play a limited but important role in treating breast cancer. For more efficient treatment, combination therapy could be an appropriate option. In this study, radiotherapy using neutron radiation emitted from a 241Am-Be neutron source, as well as biotherapy using curcumin (80 μM) was combined to investigate the efficiency of treatment towards MCF-7 breast cancer in a three dimensional (3D) culture medium.

Evaluating the effects of metal artifacts on dose distribution of the pelvic region.

Aim Of The Study: Some cancerous patients have hip prosthesis of metal elements when they undergo radiation therapy. Metal implants are a cause of metal artifacts in computed tomography (CT) images due to their higher density compared to normal tissues. The aim of this study is to evaluate the quantitative effects of metal artifacts on dose distribution of the pelvic region.

Analysis of the caregiver effective dose during I-131 therapy of thyroid.

Aims: The main objective of the present research is to analyze the caregiver effective dose during I-131 therapy of thyroid in some different situations using MCNP4C Monte Carlo code.

Patients And Methods: Two separate whole body Medical Internal Radiation Dosimetry (MIRD) phantoms have been defined simultaneously in a single Monte Carlo N-Particle (MCNP) input file as the patient and the caregiver. Two different groups of irradiation situations have been assumed for the caregiver related to the patient, (1) both the patient and the caregiver are standing and (2) the patient is lying in the bed while the caregiver is standing beside the patient.