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Publications by authors named "Mehdi Mohamad Zreik"

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MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs.
Louie Semaan Qingning Zeng Yong Lu Yi Zhang Mehdi Mohamad Zreik

Oncotarget

February 2021

Hepatocellular carcinoma (HCC) is the most common primary liver tumor worldwide. Current medical therapy for HCC has limited efficacy. The present study tests the hypothesis that human cerebral endothelial cell-derived exosomes carrying elevated miR-214 (hCEC-Exo-214) can amplify the efficacy of anti-cancer drugs on HCC cells.

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Synopsis of recent research by authors named "Mehdi Mohamad Zreik"

  • - Mehdi Mohamad Zreik's research primarily investigates the role of microRNAs in enhancing the efficacy of anti-cancer therapies, particularly focusing on hepatocellular carcinoma (HCC).
  • - In his notable study published in February 2021, Zreik explores how exosomes enriched with microRNA-214 from human cerebral endothelial cells can sensitize HCC cells to conventional anti-cancer drugs, potentially improving treatment outcomes.
  • - The findings suggest that leveraging exosome-derived microRNAs could represent a novel therapeutic strategy to overcome the limitations of current HCC treatments, highlighting the importance of miR-214 in cancer therapy enhancement.

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