Publications by authors named "Mehdi Karim"
Article Synopsis
- - The rising prevalence of diabetes mellitus (DM) has sparked interest in natural treatments, prompting studies on saffron's impact on metabolic health in diabetic patients.
- - This systematic review and meta-analysis analyzed 15 randomized controlled trials involving nearly 900 participants to assess saffron's effects on cardiometabolic markers.
- - Results indicated saffron supplementation significantly reduced fasting blood sugar, HbA1C, triglycerides, and blood pressure in participants with diabetes, suggesting its potential effectiveness as a therapeutic option.
When the yeast Saccharomyces cerevisiae sigma 1278b was starved for nitrogen, the total glutathione (GSH) pool increased from 7 to 17 nmol (mg dry wt)-1 during the first 2 h and then declined. More than 90% of the total GSH shifted towards the central vacuole during this time. This transient stimulation was not observed in the presence of buthionine-(S,R)-sulphoximine (BSO), a specific transition-state-analogue inhibitor of gamma-glutamylcysteine synthase (gamma-GCS), nor in a mutant strain deficient in this enzyme- gamma-Glutamyltranspeptidase (gamma-GT), a vacuolar enzyme responsible for the initial step of GSH degradation, was derepressed during nitrogen starvation.
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