Publications by authors named "Mehdi Hichor"

Article Synopsis
  • Diabetes leads to diabetic peripheral neuropathy (DPN), causing changes in peripheral nerves, and this study focuses on the roles of liver X receptor (LXR) signaling and NADPH oxidase-4 (Nox4) in its development.
  • Research using diabetic mouse models and human skin samples shows that reduced LXR and increased Nox4 are linked to nerve damage and myelin gene expression issues in both type 1 and type 2 diabetes.
  • Activating LXR or inhibiting Nox4 improves nerve function and restores important myelin proteins, indicating that targeting this LXR/Nox4 pathway could be a new treatment strategy for DPN.
View Article and Find Full Text PDF

Reactive oxygen species (ROS) modify proteins and lipids leading to deleterious outcomes. Thus, maintaining their homeostatic levels is vital. This study highlights the endogenous role of LXRs (LXRα and β) in the regulation of oxidative stress in peripheral nerves.

View Article and Find Full Text PDF

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in xenobiotic metabolism. Plexiform neurofibromas (PNFs) can transform into malignant peripheral nerve sheath tumors (MPNSTs) that are resistant to existing therapies. These tumors are primarily composed of Schwann cells.

View Article and Find Full Text PDF

Aims: Paraquat (PQT), a redox-active herbicide, is a free radical-producing molecule, causing damage particularly to the nervous system; thus, it is employed as an animal model for Parkinson's disease. However, its impact on peripheral nerve demyelination is still unknown. Our aim is to decipher the influence of PQT-induced reactive oxygen species (ROS) production on peripheral myelin.

View Article and Find Full Text PDF

The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols that originated from the oxidation of cholesterol. They are crucial for cholesterol homeostasis, a major lipid constituent of myelin sheaths that are formed by oligodendrocytes.

View Article and Find Full Text PDF