Publications by authors named "Mehdi Emamverdi"
Objective: The purpose of this study was to quantitatively analyze and compare OCT characteristics of intraretinal hyper-reflective foci (IHRF) in eyes with diabetic retinopathy (DR) versus age-related macular degeneration (AMD).
Design: a retrospective observational study.
Participants: 54 treatment-naïve eyes (27 DR and 27 AMD).
Peripheral retinal imaging plays a crucial role in the diagnosis, management, and prognosis of diabetic retinopathy (DR). Traditional fundus imaging techniques have limited coverage of the retina, resulting in missed peripheral lesions. The advent of ultra-widefield (UWF) imaging has revolutionized the assessment of the peripheral retina.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the effectiveness of generative adversarial networks (GANs) in predicting diabetic macular edema using optical coherence tomography (OCT) images after long-term anti-VEGF treatment.
- A total of 327 diabetic macular edema patients had their OCT images analyzed over 52 weeks, with different GAN models generating OCT images based on various inputs like baseline B-scans or additional retinal imaging data.
- The results indicated that GAN models could accurately predict residual fluid and hard exudates, suggesting their potential in identifying patients who may not respond well to treatment, thus aiding in better management strategies.
Purpose: Enface OCT may disclose a distinct "fingerprint-like' pattern within the HFL in various macular disorders. This study aims to investigate the frequency and characteristics of this pattern in healthy eyes and identify potential factors influencing its visibility.
Methods: Two, independent masked reading center graders evaluated for the presence and prominence of a fingerprint pattern in the Henle fiber layer (HFL) on enface OCT images from 33 healthy subjects (66 eyes).
Purpose: We aimed to identify structural differences in normal eyes, early age-related macular degeneration (AMD), and intermediate AMD eyes using optical coherence tomography (OCT) in a well-characterized, large cross-sectional cohort.
Methods: Subjects ≥ 60 years with healthy normal eyes, as well as early or intermediate AMD were enrolled in the Alabama Study on Age-related Macular Degeneration 2 (ALSTAR2; NCT04112667). Using Spectralis HRA + OCT2, we obtained macular volumes for each participant.
Purpose: To compare the ganglion cell complex (GCC) thickness in eyes with age-related macular degeneration (AMD) vs healthy controls in an elderly Amish population.
Design: Prospective cross-sectional study.
Methods: This is a post hoc analysis of the family-based prospective study of Amish subjects.
Purpose: The goal of this study was to evaluate and compare the intermodality and interreader agreement of manual and semiautomated geographic atrophy (GA) area measurements in eyes with GA due to age-related macular degeneration (AMD) using conventional blue-light fundus autofluorescence (FAF) and ultrawidefield (UWF) green-light FAF systems.
Design: Prospective Cohort Study.
Subjects: Seventy-two eyes of 50 patients with a diagnosis of advanced nonneovascular AMD with GA.
Purpose: This study aims to define the characteristics of acquired vitelliform lesions (AVLs) in patients with intermediate age-related macular degeneration (iAMD).
Design: Retrospective, observational, cross sectional study.
Subjects: This study included 217 eyes with AVLs associated with iAMD, and an equivalent number of control patients.
Inherited retinal diseases (IRDs) represent one of the major causes of progressive and irreversible vision loss in the working-age population. Over the last few decades, advances in retinal imaging have allowed for an improvement in the phenotypic characterization of this group of diseases and have facilitated phenotype-to-genotype correlation studies. As a result, the number of clinical trials targeting IRDs has steadily increased, and commensurate to this, the need for novel reproducible outcome measures and endpoints has grown.
View Article and Find Full Text PDFPurpose: In this study, we identify risk factors that predict the progression of acquired vitelliform lesions (AVLs) over time.
Design: Retrospective cohort study.
Subjects: One hundred sixty-three eyes of 132 patients with a diagnosis of intermediate age-related macular degeneration (iAMD) with AVL.
Aims: The aim of this study is to assess baseline characteristics of drusen preceding the development of intraretinal hyper-reflective foci (IHRF) in eyes with intermediate age-related macular degeneration (AMD).
Methods: In this retrospective case-control study, longitudinal optical coherence tomography (OCT) volume data from eyes with intermediate AMD in a retina clinic population were screened. All drusen that developed overlying IHRF were marked.
Purpose: To define optical coherence tomography (OCT) biomarkers that precede the development of complete retinal pigment epithelium and outer retinal atrophy (cRORA) at that location in eyes with age-related macular degeneration (AMD).
Methods: In this retrospective case-control study, patients with dry AMD who had evidence of cRORA and OCT data available for 4 years (48 ± 4 months) prior to the first visit with evidence of cRORA were included. The visit 4 years prior to the development of cRORA was defined as the baseline visit, and the region on the OCT B-scans of future cRORA development was termed the case region.
Purpose: To evaluate the optical coherence tomography (OCT) features of hyperpigmented lesions in the absence of intraretinal hyperreflective foci (IHRF) on OCT in eyes with age-related macular degeneration (AMD).
Methods: We retrospectively analyzed OCT images of eyes with intermediate AMD (iAMD) and macular hyperpigmentation (HP) on color fundus photograph (CFP) but without IHRF on OCT in the corresponding location. The most prominent or definite HP was selected for analysis.
Article Synopsis
- * It included 60 patients over 60 years old with AMD, who underwent OCT scanning; trained graders then analyzed the scans for specific features of atrophy and other AMD characteristics.
- * Results showed HR-OCT had higher accuracy and reliability in classifying atrophic lesions and provided better agreement among readers for qualitative and quantitative features than standard OCT.
Background: To determine the effect of ketorolac tromethamine 0.5% in preventing post-phacoemulsification macular thickening. This randomized clinical trial.
View Article and Find Full Text PDFPurpose: To evaluate the changes in macular blood flow after cataract surgery through optical coherence tomography angiography (OCT-A).
Methods: In this prospective case series, 50 patients who underwent uncomplicated cataract surgery by the resident were included. OCT-A images and complete ocular examinations were performed at baseline, 1 and 3 months postoperatively.
Purpose: To investigate the effects of peripheral ischemic retinal photocoagulation in addition to intravitreal bevacizumab (IVB) in the treatment of macular edema due to ischemic central retinal vein occlusion.
Methods: Forty-eight eyes of 48 treatment-naive patients were randomly selected and divided into 2 groups. Group A comprised 24 eyes that were treated with three consecutive monthly injections of IVB, and Group B comprised 24 eyes that were treated with IVB plus photocoagulation of the peripheral nonperfused retina.