Production of Cartilaginous Organoids: Potential Opportunities and Challenges, A Review Article.

Damaged articular cartilage has limited self-healing potential and often leads to osteoarthritis (OA), pain, and dysfunction of the affected joint. Autologous and allogenic transplants cannot fully meet the needs of clinical treatment. Two dimensional (2D) and three-dimensional (3D) cell cultures can help to study growth modeling and physiological characteristics of the human body.

The psychological toll of the COVID-19 pandemic on dental care providers in Iran: A multicenter cross-sectional study.

Background/purpose: The COVID-19 pandemic affects social and psychological resources. Healthcare workers, especially dental personnel, are more at risk for mental issues due to anxiety, pressure, and frustration. This study assessed mental health outcomes during the COVID-19 epidemic among Iranian dental care providers, focusing on insomnia, anxiety, depression, and posttraumatic stress disorder (PTSD).

Predicting the effect of a combination drug therapy on the prostate tumor growth via an improvement of a direct radial basis function partition of unity technique for a diffuse-interface model.

Chemotherapy is usually applied to treat advanced prostate cancer that cancer cells spread outside the prostate gland. The treatment uses cytotoxic drugs to target cells that grow and divide quickly. On the other hand, the growth of such cancerous tumors depends on angiogenesis.

The numerical solution of a mathematical model of the Covid-19 pandemic utilizing a meshless local discrete Galerkin method.

It was in early December 2019 that the terrible news of the outbreak of new coronavirus disease (Covid-19) was reported by the world media, which appeared in Wuhan, China, and is rapidly spreading to other parts of China and several overseas countries. In the field of infectious diseases, modeling, evaluating, and predicting the rate of disease transmission are very important for epidemic prevention and control. Several preliminary mathematical models for Covid-19 are formulated by various international study groups.

The correlation between osseointegration and bonding strength at the bone-implant interface: In-vivo & ex-vivo investigations on hydroxyapatite and hydroxyapatite/titanium coatings.

This study investigated the effects of hydroxyapatite (HA) and hydroxyapatite/titanium (HA/Ti) coatings on osseointegration and bonding strength at the bone-implant interface. The coatings were made using air plasma spray (APS), and three study groups were examined: 1) Uncoated commercial pure titanium (CP-Ti) rods; 2) HA-coated CP-Ti rods, and 3) Composite of 50 %wt HA + 50 %wt Ti coated CP-Ti rods. The rods were implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, and 8 weeks after the implantation, the samples were harvested.

Verbal and oral apraxia in patients with acute stroke: Frequency, relationship, and some risk factors.

Verbal and oral apraxia are two possible consequences of stroke. It seems that there are not sufficient studies regarding the frequency of these disorders. This study aimed to evaluate the frequency of Verbal and oral apraxia.

Dental implants' stability dependence on rotational speed and feed-rate of drilling: In-vivo and ex-vivo investigations.

This study aimed to explore the effects of drilling rotational speed and feed-rate on the stability of dental implants through in-vivo and ex-vivo experiments. To this end, a total of 16 identical dental implants were inserted in the mandible of four dogs. The osteotomies were made with two drilling rotational speeds, i.

Generalized moving least squares approximation for the solution of local and non-local models of cancer cell invasion of tissue under the effect of adhesion in one- and two-dimensional spaces.

The main aim of this study is to solve numerically the mathematical models showing cancer cell invasion of tissue with/without considering the effect of cell-cell and cell-matrix adhesion. The mathematical models studied here are the systems of time-dependent reaction-diffusion-taxis equations in one- and two-dimensional spaces, which are formulated in the local and non-local forms. There are some difficulties in finding their solutions via numerical methods.

Radial basis function-generated finite difference scheme for simulating the brain cancer growth model under radiotherapy in various types of computational domains.

Background And Objectives: We extend the original mathematical model, i.e., Swanson's reaction-diffusion equation to the surfaces with no boundary, and we find a new numerical method based on a meshless approach for solving numerically Swanson's reaction-diffusion model in the square and on the sphere.

Effects of Rheumatoid Arthritis on the Larynx.

Introduction: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls.

Materials And Methods: This case-control descriptive study was performed on 113 people, including 50 patients with rheumatoid arthritis and 63 controls. The participants were subjected to videolaryngostroboscopic examinations in order to evaluate fundamental frequency, different structural vocal lesions, patterns of glottal closure, subglottal changes, supraglottis appearance, and movement patterns of the arytenoid cartilage.

Speech and language development of children born following assisted reproductive technologies.

Objectives: Studies which targeted communication skills of children born following assisted reproductive technologies have reported contradictory results. Concerning the increasing rates of children born in these technologies and the importance of some factors as risk factors like birth weight, gestational age, and the number of children per birth in these procedures, studying speech and language skills is critical. So, the current study aimed to investigate the speech and language capabilities of Persian speaking children born following these procedures.

A multilevel Monte Carlo finite element method for the stochastic Cahn-Hilliard-Cook equation.

In this paper, we employ the multilevel Monte Carlo finite element method to solve the stochastic Cahn-Hilliard-Cook equation. The Ciarlet-Raviart mixed finite element method is applied to solve the fourth-order equation. In order to estimate the mild solution, we use finite elements for space discretization and the semi-implicit Euler-Maruyama method in time.

Translation, Validity, and Reliability of the Persian Version of the Aging Voice Index.

Objectives: The Aging Voice Index (AVI) was developed to study quality of life in older adults with voice disorders. The purpose of this study was to translate the original English version of the AVI to Persian version of Aging Voice Index (P-AVI) and validate the P-AVI for the Persian-speaking older adults with voice disorders.

Methods: A cross-sectional, descriptive, and methodological study was performed to translate and validate the Persian version of the AVI.

A comprehensive survey of energy-aware routing protocols in wireless body area sensor networks.

Wireless body area sensor network is a special purpose wireless sensor network that, employing wireless sensor nodes in, on, or around the human body, makes it possible to measure biological parameters of a person for specific applications. One of the most fundamental concerns in wireless body sensor networks is accurate routing in order to send data promptly and properly, and therefore overcome some of the challenges. Routing protocols for such networks are affected by a large number of factors including energy, topology, temperature, posture, the radio range of sensors, and appropriate quality of service in sensor nodes.

Candida laryngitis appearing as carcinoma.

Background: Focal laryngeal candidiasis is not reported widely and is very infrequently recognized clinically. This disease is rare and may occur after pulmonary, pharyngeal and esophageal candidiasis or as part of disseminated disease. It is also secondary to inhaled steroid therapy which is usually mild and has been reported in 10-15 percent of patients taking these medications.

Learning Stationary Correlated Equilibria in Constrained General-Sum Stochastic Games.

We study constrained general-sum stochastic games with unknown Markovian dynamics. A distributed constrained no-regret Q -learning scheme (CNR Q ) is presented to guarantee convergence to the set of stationary correlated equilibria of the game. Prior art addresses the unconstrained case only, is structured with nested control loops, and has no convergence result.

Etiologies of Dysphonia in Patients Referred to ENT Clinics Based on Videolaryngoscopy.

Introduction: Laryngeal dysfunction may be divided into three categories; organic, neurologic and functional disorders. Dysphonia and hoarseness are the most common symptoms and, in some cases, the only signs of laryngeal dysfunction. In differential diagnosis of any type of chronic hoarseness, a neoplastic process must be considered and, thus continuous light video laryngoscopy can provide important information on the presence of neoplastic lesions in order to prevent disease progression via early detection and action.

Verification of the mechanostat theory in mandible remodeling after tooth extraction: animal study and numerical modeling.

Bone tissue is capable of remodeling in response to environmental and physiological conditions. Mechanical loading is thought to be one of the most important environmental factors, affecting bone status. Mechanostat theory, which classifies bone behavior on the basis of the mechanical strain, has been vastly applied in cases of long bones.

Monitoring of cytomegalovirus reactivation in bone marrow transplant recipients by real-time PCR.

Cytomegalovirus (CMV) has been recognized as the most important viral pathogen in persons undergoing bone marrow transplantation (BMT). The aim was to develop a quantitative PCR assay to quantify CMV DNA in peripheral blood leukocytes (PBLs) of bone marrow transplantation (BMT) patients. An in-house real-time PCR assay based on TaqMan technology was developed to monitor the quantity of CMV DNA in PBLs of the BMT recipients.