Population pharmacokinetics of bupivacaine in combined lumbar and sciatic nerve block.

Objectives: The primary aim of this study was to establish the population pharmacokinetic (PPK) model of bupivacaine after combined lumbar plexus and sciatic nerve blocks and secondary aim is to assess the effect of patient's characteristics including age, body weight and sex on pharmacokinetic parameters.

Materials And Methods: A total of 31 patients scheduled for elective lower extremity surgery with combined lumbar and sciatic nerve block using plain bupivacaine 0.5% were included.

Effects of intrathecal midazolam on postoperative analgesia when added to a bupivacaine-clonidine mixture.

Background: Previous clinical and experimental studies have shown that a midazolam-clonidine mixture has a synergistic antinociceptive effect. This study evaluated the postoperative analgesic effect of adding midazolam to an intrathecal bupivacaine-clonidine mixture.

Methods: One hundred ten patients scheduled to undergo elective lower-extremity surgery were enrolled in this double-blind, randomized trial.

Co-analgesic effect of ketorolac after thoracic surgery.

Thoracotomies are painful surgical procedures and adequate pain relief is associated with improved respiratory function and fewer respiratory complications. After thoracotomy for lung resection, patients received morphine-based patient-controlled analgesia (PCA). Three groups were prospectively and randomised investigated: patients receiving preemptive ketorolac, those given postoperative ketorolac and controls.

[Comparison of three protocols in the control of cardiovascular response to suspended laryngoscopy in ENT surgery].

The objective was to compare the effect of three pharmacological agents on the hemodynamic response to suspended laryngoscopy in micro ENT Surgery. Double blind randomised prospective study having included: groupe A (n = 16) having benefited before laryngoscopy of 150 mcg/kg esmolol, groupe B (n = 16) 15 mcg/kg of nicardipine, groupe C (n = 15) 1 mg/kg of lidocaine and groupe D (n = 16), placebo group. All groups were comparable for demographic and anesthetic data.