A Comparative Study of Ni-Based Catalysts Prepared by Various Sol-Gel Routes.

The use of heterogeneous catalysts to increase the development of green chemistry is a rapidly growing area of research to save industry money. In this paper, mesoporous SiO-AlO mixed oxide supports with various Si/Al ratios were prepared using two different sol-gel routes: hydrolytic sol-gel (HSG) and non-hydrolytic sol-gel (NHSG). The HSG route was investigated in both acidic and basic media, while the NHSG was explored in the presence of ethanol and diisopropyl ether as oxygen donors.

Easily deposited ZnO nanorods on siloxene nanosheets: investigation of morphological, dielectric, ferroelectric, and energy storage properties.

The integration of metal oxides onto two-dimensional layered siloxene has proven to be an effective strategy for expanding potential applications across diverse fields. Herein, we present the synthesis and detailed characterization of zinc oxide (ZnO) nanorods deposited on siloxene nanosheets using the wet chemical precipitation method without the need of alkali. The presence of ZnO nanorods was confirmed through electron microscopy analyses.

Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents.

With the aim to identify new antiviral agents with antibacterial properties, a series of 2-quinolone-1,2,3-triazole derivatives bearing α-aminophosphonates was synthesized and characterized by H NMR, C NMR, P NMR, single crystal XRD and HRMS analyses. These compounds were examined against five RNA viruses (YFV, ZIKV, CHIKV, EV71 and HRV) from three distinct families (Picornaviridae, Togaviridae and Flaviviridae) and four bacterial strains (S. aureus, E.

Selective Functionalization of Carbonyl -Decaborate [2-BHCO] with Building Block Properties via Grignard Reagents.

A green, fast and selective approach for the synthesis of mono-substituted -decaborate derivatives [2-BHCOR] has been established via a nucleophilic addition reaction between the carbonyl derivative of -decaborate [2-BHCO] and the corresponding Grignard reagent RMgX, where R is the ethyl, iso-propyl, pentyl, allyl, vinyl and propynyl groups. This approach is accomplished under mild conditions with 70-80% yields. The significance of these derivative is their ability to constitute building blocks for polymeric integration via the allyl, vinyl and propynyl substituents.

Gelatin modified with alkoxysilanes (GelmSi) forms hybrid hydrogels for bioengineering applications.

Biopolymers are ideal candidates for the development of hydrogels for tissue engineering applications. However, chemical modifications are required to further improve their mechanical properties, in particular to cross-link them for long-lasting applications or biofabrication. Herein, we developed a novel gelatin-based hydrogel precursor, "GelmSi" which consist on modified gelatin with triethoxysilyl groups.

Long-term stable solid concentrated graphene dispersion assisted by a highly aromatic ionic liquid.

Hypothesis: The sonochemical exfoliation of graphite in solution has been demonstrated as a promising and easy technique for producing graphene dispersions. This is usually done in organic solvents and leads to unstable dispersions with very low graphene concentration. Ionic liquids (ILs) represent a versatile and safe alternative to traditional organic solvents.

Silylated biomolecules: Versatile components for bioinks.

Physical hydrogels prepared from natural biopolymers are the most popular components for bioinks. However, to improve the mechanical properties of the network, in particular its durability for long-lasting tissue engineering applications or its stiffness for bone/cartilage applications, covalent chemical hydrogels have to be considered. For that purpose, biorthogonal reactions are required to allow the inclusion of living cells within the bioink reservoir before the 3D printing procedure.

Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents.

A new series of 3-acetyl-1,3,4-oxadiazoline hybrid molecules was designed and synthesized using a condensation between acyclonucleosides and substituted phenylhydrazone. All intermediates and final products were screened against Leishmania donovani, a Protozoan parasite and against three viruses SARS-CoV-2, HCMV and VZV. While no significant activity was observed against the viruses, the intermediate with 6-azatymine as thymine and 5-azathymine-3-acetyl-1,3,4-oxadiazoline hybrid exhibited a significant antileishmanial activity.

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives.

Analogs of pyrimidine and 1,3,4-oxadiazole are two well established class of molecules proven as potent antiviral and anticancer agents in the pharmaceutical industry. We envisioned designing new molecules where these two heterocycles were conjugated with the goal of enhancing biological activity. In this vein, we synthesized a series of novel pyrimidine-1,3,4-oxadiazole conjugated hybrid molecules as potential anticancer and antiviral agents.

Textural control of ionosilicas by ionic liquid templating.

Due to their unique self-assembly properties, ionic liquids (ILs) are versatile soft templates for the formation of mesoporous materials. Here, we report the use of ionic liquids as soft templates for the straightforward formation of mesoporous ionosilica phases. Ionosilicas are highly polyvalent functional materials that are constituted of ionic building blocks that are covalently immobilized within a silica hybrid matrix.

Encapsulation of BSA in hybrid PEG hydrogels: stability and controlled release.

Hybrid hydrogels based on silylated polyethylene glycol, Si-PEG, were evaluated as hybrid matrices able to trap, stabilize and release bovine serum albumin (BSA) in a controlled manner. Parameters of the inorganic condensation reaction leading to a siloxane (Si-O-Si) three dimensional network were carefully investigated, in particular the temperature, the surrounding hygrometry and the Si-PEG concentration. The resulting hydrogel structural features affected the stability, swelling, and mechanical properties of the network, leading to different protein release profiles.

Hydrolytic vs. Nonhydrolytic Sol-Gel in Preparation of Mixed Oxide Silica-Alumina Catalysts for Esterification.

The development of green and sustainable materials for use as heterogeneous catalysts is a growing area of research in chemistry. In this paper, mesoporous SiO-AlO mixed oxide catalysts with different Si/Al ratios were prepared via hydrolytic (HSG) and nonhydrolytic sol-gel (NHSG) processes. The HSG route was explored in acidic and basic media, while NHSG was investigated in the presence of diisopropylether as an oxygen donor.

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema.

Objectives: Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes significant impairment to mobility and quality-of-life. To identify molecular mechanisms underpinning lipedema, we employed comprehensive omics-based comparative analyses of whole tissue, adipocyte precursors (adipose-derived stem cells (ADSCs)), and adipocytes from patients with or without lipedema.

Methods: We compared whole-tissues, ADSCs, and adipocytes from body mass index-matched lipedema (n = 14) and unaffected (n = 10) patients using comprehensive global lipidomic and metabolomic analyses, transcriptional profiling, and functional assays.

Development of Amino Acids Functionalized SBA-15 for the Improvement of Protein Adsorption.

Ordered mesoporous materials and their modification with multiple functional groups are of wide scientific interest for many applications involving interaction with biological systems and biomolecules (e.g., catalysis, separation, sensor design, nano-science or drug delivery).

A Collagen-Mimetic Organic-Inorganic Hydrogel for Cartilage Engineering.

Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the injured joint. Preclinical and clinical data using MSCs embedded in a collagen gel have demonstrated improvements in patients with focal lesions and osteoarthritis. However, an improvement is often observed in the short or medium term due to the loss of the chondrocyte capacity to produce the correct extracellular matrix and to respond to mechanical stimulation.

Discovery of novel furo[2,3-d]pyrimidin-2-one-1,3,4-oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis.

A new series of furo[2,3-d]pyrimidine-1,3,4-oxadiazole hybrid derivatives were synthesized via an environmentally friendly, multistep synthetic tool and a one-pot Songoashira-heterocyclization protocol using, for the first time, nanostructured palladium pyrophosphate (Na PdP O ) as a heterogeneous catalyst. Compounds 9a-c exhibited broad-spectrum activity with low micromolar EC values toward wild and mutant varicella-zoster virus (VZV) strains. Compound 9b was up to threefold more potent than the reference drug acyclovir against thymidine kinase-deficient VZV strains.

The Effect of Size and Thermal Treatment on the Photoluminescent Properties of Europium-Doped SiO Nanoparticles Prepared in One Pot by Sol-Gel.

Europium (Eu)-doped silica nanoparticles have attracted great interest for different applications, in particular in biomedicine as biosensors or for tissue regeneration. Sol-gel is the most common process used to prepare those particles, with size varying from tens to hundreds of nanometers. In this article, we focus our attention on the comparison between two commonly used sol-gel derived methods: reverse microemulsion (for particles smaller than 100 nm) and Stöber method (for particles larger than 100 nm).

Sol-gel process: the inorganic approach in protein imprinting.

Proteins play a central role in the signal transmission in living systems since they are able to recognize specific biomolecules acting as cellular receptors, antibodies or enzymes, being themselves recognized by other proteins in protein/protein interactions, or displaying epitopes suitable for antibody binding. In this context, the specific recognition of a given protein unlocks a range of interesting applications in diagnosis and in targeted therapies. Obviously, this role is already fulfilled by antibodies with unquestionable success.

When graphene meets ionic liquids: a good match for the design of functional materials.

Graphene is an attractive material that is characterized by its exceptional properties (i.e. electrical, mechanical, thermal, optical, etc.

Design of PEGylated Three Ligands Silica Nanoparticles for Multi-Receptor Targeting.

The synthesis of silica nanoparticles (SiNPs) decorated on their surface with a range of various elements (e.g., ligands, drugs, fluorophores, vectors, etc.

Design, synthesis, biological evaluation and molecular docking of new 1,3,4-oxadiazole homonucleosides and their double-headed analogs as antitumor agents.

A novel series of homonucleosides and their double-headed analogs containing theophylline, 1,3,4-oxadiazole, and variant nucleobases was designed and synthesized. The new derivatives were fully characterized by HRMS, FT-IR, H NMR, and C NMR. The cytotoxic activities of all prepared compounds were screened in vitro against four cell lines, including fibrosarcoma (HT-1080), breast (MCF-7 and MDA-MB-231), and lung carcinoma (A-549).

Removal of biogenic amines from wines by chemisorption on functionalized silica and effects on other wine components.

The effectiveness of several functionalized silica materials (cation-exchange materials) for the removal of biogenic amines from wines, and the effects on other wine components and organoleptic characteristics were evaluated. Results have shown that mesoporous silica material bi-functionalized with phosphonic and sulfonic acids allowed the removal of histamine, putrescine, cadaverine, spermine and spermidine from wines, although the dose must be adapted for each wine according to the removal requirements and wine characteristics. A plus of the adsorbent developed is that it can be recovered and re-used for at least 3 treatments.

Solid-Liquid Europium Ion Extraction via Phosphonic Acid-Functionalized Polyvinylidene Fluoride Siloxanes.

Novel triethoxysilane and dimethyl phosphonate functional vinylidene fluoride (VDF)-containing terpolymers, for potential applications in Eu ion extraction from water, were produced by conventional radical terpolymerization of VDF with vinyltriethoxylsilane (VTEOS) and vinyldimethylphosphonate (VDMP). Although initial attempts for the copolymerization of VTEOS and VDMP failed, the successful terpolymerization was initiated by peroxide to lead to multiple poly(VDF--VDMP--VTEOS) terpolymers, that had different molar percentages of VDF (70-90 mol.%), VTEOS (5-20 mol.