Development and Optimization of Lipid-polymer Hybrid Nanoparticles Containing Melphalan Using Central Composite Design and Its Effect on Ovarian Cancer Cell Lines.

The development of controlled-release drug delivery systems has a great potential to improve the efficacy of anticancer drugs. This study aimed to develop and optimize the production of hybrid lipid-polymer nanoparticles () for the targeted delivery of anticancer drugs. Response surface methodology () and central composite design () were used to evaluate and optimize the effects of three independent variables including lipid, polymer, and polyvinyl alcohol () ratios on the nanoparticles () size and drug entrapment efficiency (%).