Publications by authors named "Megumi Yamanishi"
Lymphangioleiomyomatosis (LAM) is one of the presentations of perivascular epithelioid cell neoplasm that is frequently complicated by tuberous sclerosis complex (TSC). Here, we report an uncommon case of uterine LAM treated with everolimus, which is a mechanistic target of rapamycin (mTOR) inhibitor. A 42-year-old female patient (gravida 0) with a history of TSC presented with abdominal pain.
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- - The study aimed to evaluate the effectiveness of imiquimod in treating vaginal intraepithelial neoplasia (VaIN) 2-3, as there has been no established treatment strategy for this condition.
- - Researchers analyzed data from 5 articles and clinical records of patients treated with imiquimod, finding a pooled complete response rate of 76% and an overall response rate of 89%.
- - Results indicated that imiquimod is potentially effective for VaIN 2-3, particularly in patients with a history of hysterectomy, who showed a higher complete response rate compared to those without.
Vaginal intraepithelial neoplasia (VAIN) is a rare disease associated with human papillomavirus infection. High-grade VAIN is typically treated with either excisional or ablative therapy. However, recurrent VAIN lesions are common and these treatments cause vaginal scarring.
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